Mobilization of colony-forming cells (CFU-C) into the peripheral blood of man by hydrocortisone

L. Morra; A. Ponassi; G. B. Parodi; G. Caristo; P. Bruzzi; C. Sacchetti

Mobilization of colony-forming cells (CFU-C) into the peripheral blood of man by hydrocortisone

L. Morra, A. Ponassi, G. B. Parodi, G. Caristo, P. Bruzzi, C. Sacchetti

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of hydrocortisone on blood CFU-C has been studied in six normal subjects through a double layer agar culture system. Increased numbers of CFU-C appeared in the peripheral blood reaching a maximum 366% to 631% increase 5-8 hours after the i.v. administration of the hormone. Contemporary lymphopenia caused a 4 to 10 fold enrichment in the proportion of CFU-C to lymphocytes. Hydrocortisone added in vitro somewhat inhibited the colony growth. The results suggest that the increase of blood CFU-C is due to mobilization from the bone marrow. Hydrocortisone, when compared to other agents, appears to offer some advantages in increasing the blood CFU-C for clinical purposes.

Original language	English
Pages (from-to)	87-90
Number of pages	4
Journal	Biomedicine Express
Volume	35
Issue number	3
Publication status	Published - 1981

ASJC Scopus subject areas

Medicine(all)

Fingerprint Dive into the research topics of 'Mobilization of colony-forming cells (CFU-C) into the peripheral blood of man by hydrocortisone'. Together they form a unique fingerprint.

Cite this

@article{bf18fdd01e3a4810812554fa61a7eab7,

title = "Mobilization of colony-forming cells (CFU-C) into the peripheral blood of man by hydrocortisone",

abstract = "The effect of hydrocortisone on blood CFU-C has been studied in six normal subjects through a double layer agar culture system. Increased numbers of CFU-C appeared in the peripheral blood reaching a maximum 366% to 631% increase 5-8 hours after the i.v. administration of the hormone. Contemporary lymphopenia caused a 4 to 10 fold enrichment in the proportion of CFU-C to lymphocytes. Hydrocortisone added in vitro somewhat inhibited the colony growth. The results suggest that the increase of blood CFU-C is due to mobilization from the bone marrow. Hydrocortisone, when compared to other agents, appears to offer some advantages in increasing the blood CFU-C for clinical purposes.",

author = "L. Morra and A. Ponassi and Parodi, {G. B.} and G. Caristo and P. Bruzzi and C. Sacchetti",

year = "1981",

language = "English",

volume = "35",

pages = "87--90",

journal = "Biomedicine Express",

issn = "0300-0885",

publisher = "Masson Publishing",

number = "3",

}

TY - JOUR

T1 - Mobilization of colony-forming cells (CFU-C) into the peripheral blood of man by hydrocortisone

AU - Morra, L.

AU - Ponassi, A.

AU - Parodi, G. B.

AU - Caristo, G.

AU - Bruzzi, P.

AU - Sacchetti, C.

PY - 1981

Y1 - 1981

N2 - The effect of hydrocortisone on blood CFU-C has been studied in six normal subjects through a double layer agar culture system. Increased numbers of CFU-C appeared in the peripheral blood reaching a maximum 366% to 631% increase 5-8 hours after the i.v. administration of the hormone. Contemporary lymphopenia caused a 4 to 10 fold enrichment in the proportion of CFU-C to lymphocytes. Hydrocortisone added in vitro somewhat inhibited the colony growth. The results suggest that the increase of blood CFU-C is due to mobilization from the bone marrow. Hydrocortisone, when compared to other agents, appears to offer some advantages in increasing the blood CFU-C for clinical purposes.

AB - The effect of hydrocortisone on blood CFU-C has been studied in six normal subjects through a double layer agar culture system. Increased numbers of CFU-C appeared in the peripheral blood reaching a maximum 366% to 631% increase 5-8 hours after the i.v. administration of the hormone. Contemporary lymphopenia caused a 4 to 10 fold enrichment in the proportion of CFU-C to lymphocytes. Hydrocortisone added in vitro somewhat inhibited the colony growth. The results suggest that the increase of blood CFU-C is due to mobilization from the bone marrow. Hydrocortisone, when compared to other agents, appears to offer some advantages in increasing the blood CFU-C for clinical purposes.

UR - http://www.scopus.com/inward/record.url?scp=0019823757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019823757&partnerID=8YFLogxK

M3 - Article

C2 - 7272426

AN - SCOPUS:0019823757

VL - 35

SP - 87

EP - 90

JO - Biomedicine Express

JF - Biomedicine Express

SN - 0300-0885

IS - 3

ER -

Mobilization of colony-forming cells (CFU-C) into the peripheral blood of man by hydrocortisone

Abstract

ASJC Scopus subject areas

Other files and links

Cite this