Mobilization of colony-forming cells (CFU-C) into the peripheral blood of man by hydrocortisone

L. Morra, A. Ponassi, G. B. Parodi, G. Caristo, P. Bruzzi, C. Sacchetti

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of hydrocortisone on blood CFU-C has been studied in six normal subjects through a double layer agar culture system. Increased numbers of CFU-C appeared in the peripheral blood reaching a maximum 366% to 631% increase 5-8 hours after the i.v. administration of the hormone. Contemporary lymphopenia caused a 4 to 10 fold enrichment in the proportion of CFU-C to lymphocytes. Hydrocortisone added in vitro somewhat inhibited the colony growth. The results suggest that the increase of blood CFU-C is due to mobilization from the bone marrow. Hydrocortisone, when compared to other agents, appears to offer some advantages in increasing the blood CFU-C for clinical purposes.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalBiomedicine Express
Volume35
Issue number3
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Medicine(all)

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