Nowadays the first choice procedure to collect hematopoietic progenitor cells for autografts is the harvest of peripheral blood progenitor cells (PBPC) mobilized with cytokines, associated or not with chemotherapy. A large amount of data is available on factors affecting mobilization, such as sex, age, number of previous chemotherapy regimens, radiotherapy, and exposure to fludarabine. The individual response to mobilization is, however, highly variable from patient to patient and only a few studies have investigated biological parameters that could predict successful mobilization of P BPC for a single patient when a given regimen is employed. Findings of this study show that when G-CSF is used as a single mobilizing agent, the baseline PBPC has a predictive value.
|Number of pages||2|
|Publication status||Published - 2000|
- PBSC transplantation
- Steady state CD34 cells
ASJC Scopus subject areas