Mobilization/Transplantation of peripheral blood progenitor cells for aggressive non-Hodgkin's lymphoma with marrow involvement

G. Santini, A. M. Congiu, S. Nati, L. Canepa, M. Spriano, T. Chisesi, E. Rossi, R. Vimercati, M. R. Sertoli, O. Figari, M. Gobbi, G. Piaggio, F. Vassallo, F. Benvenuto, M. Soracco, M. Miglino, J. L. Ravetti, M. Truini

Research output: Contribution to journalArticlepeer-review

Abstract

Thirty-five aggressive non-Hodgkin's lymphomas (NHL) with marrow involvement received high-dose cyclophosphamide (7 g/m2) and G-CSF in order to collect peripheral blood progenitor cells (PBPC). Fourteen patients were in partial remission, 16 patients were in relapse ('sensitive', 12; 'resistant', 4) and 5 patients were in refractory to conventional treatment. A good yield of PBPC was obtained in 30 patients, while a low number of CD34+ cells and of CFU-GM was seen in two cases. Two patients entered progression and one patient died. Thirty patients underwent PBPC autografting. Twenty-nine out of 35 (83%) patients entered complete remission (CR). Two patients died in CR of infection following marrow aplasia 3 and 6 months after autografting. At 3 years the probability of survival and disease-free survival (DFS) are of 62% and 51% respectively.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalLeukemia and Lymphoma
Volume26
Issue numberSUPPL. 1
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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