Mobilizing potential of ifosfamide/vinorelbine-based chemotheraphy in pretreated malignant lymphoma

M. Magagnoli, B. Sarina, M. Balzarotti, L. Castagna, I. Timofeeva, A. Nozza, A. Bertuzzi, L. Siracusano, M. Sinnone, A. Santoro

Research output: Contribution to journalArticle

Abstract

The mobilizing potential and therapeutic activity of ifosfamide/vinorelbine-containing regimens with G-CSF support were explored in patients with pretreated malignant lymphomas. Ten patients with non-Hodgkin's lymphoma (NHL) received ifosfamide and vinorelbine, and 17 with Hodgkin's disease (HD) received ifosfamide, vinorelbine and gemcitabine (IGEV regimen), as induction chemotherapy before high-dose chemotherapy (HDT) with peripheral blood stem cell (PBSC) support. Most of the patients had been heavily pretreated with various chemotherapy regimens ± radiotherapy. The target yield was ≥3 × 106 CD34+ cells/kg of body weight in order to support the subsequent myeloablative chemotherapy. The optimal PBSC harvest occurred on days 11 and 12, with no difference in CD34+ cell mobilization kinetics between the ifosfamide/vinorelbine and IGEV regiments. The median number of CD34+ cells/kg body weight collected was 10.9 × 106 (range 1.76-61.1 × 106). The median total CD34+ cell/μ, CFU-GM and white blood cells (WBC) for all individual collections was 81.5/μ, 10 × 104/kg, and 17 900/μ, respectively. The target yield of CD34+ cells was reached in 24 of 27 patients. Hematological side-effects were acceptable and no treatment-related hospitalizations or toxic deaths occurred. Fifteen patients have so far received high-dose therapy and PBSC reinfusion with rapid engraftment. These results confirm that ifosfamide and vinorelbine-based chemotherapy regimen with G-CSF support can be successfully and safely used to mobilize PBSCs.

Original languageEnglish
Pages (from-to)923-927
Number of pages5
JournalBone Marrow Transplantation
Volume28
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • CD34 cells
  • Combination therapy
  • G-CSF
  • Malignant lymphoma
  • PBSC mobilization

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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