Modafinil-induced changes in functional connectivity in the cortex and cerebellum of healthy elderly subjects

Research output: Contribution to journalArticle

Abstract

In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent. To that aim, participants (n = 24) were investigated with resting state functional Magnetic Resonance Imaging (rs-fMRI) before and after the administration of a single dose (100 mg) of modafinil. Effects were compared to age and size-matched placebo group. Rs-fMRI effects were assessed, employing a graph-based approach and Eigenvector Centrality (EC) analysis, by taking in account topological changes occurring in functional brain networks. The main finding of the study is that modafinil promotes enhanced centrality, a measure of the importance of nodes within functional networks, of the bilateral primary visual (V1) cortex. EC analysis also revealed that modafinil-treated subjects show increased functional connectivity between the V1 and specific cerebellar (Crus I, Crus II, VIIIa lobule) and frontal (right inferior frontal sulcus and left middle frontal gyrus) regions. Present findings provide functional data supporting the hypothesis that modafinil can modulate the cortico-cerebellar connectivity of the aging brain.

Original languageEnglish
Article number85
JournalFrontiers in Aging Neuroscience
Volume9
Issue numberMAR
DOIs
Publication statusPublished - Mar 30 2017

Fingerprint

Cerebellum
Healthy Volunteers
Brain
Wakefulness-Promoting Agents
Magnetic Resonance Imaging
Pharmaceutical Preparations
Visual Cortex
Prefrontal Cortex
Dementia
Young Adult
Research Design
Placebos
modafinil
Research

Keywords

  • Aging
  • Cognitive enhancing drugs
  • Connectivity
  • Dopamine
  • Eigenvector centrality
  • Graph theory
  • Resting state fMRI

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

Cite this

@article{81a504f143374fcb9f3448b1501fb066,
title = "Modafinil-induced changes in functional connectivity in the cortex and cerebellum of healthy elderly subjects",
abstract = "In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent. To that aim, participants (n = 24) were investigated with resting state functional Magnetic Resonance Imaging (rs-fMRI) before and after the administration of a single dose (100 mg) of modafinil. Effects were compared to age and size-matched placebo group. Rs-fMRI effects were assessed, employing a graph-based approach and Eigenvector Centrality (EC) analysis, by taking in account topological changes occurring in functional brain networks. The main finding of the study is that modafinil promotes enhanced centrality, a measure of the importance of nodes within functional networks, of the bilateral primary visual (V1) cortex. EC analysis also revealed that modafinil-treated subjects show increased functional connectivity between the V1 and specific cerebellar (Crus I, Crus II, VIIIa lobule) and frontal (right inferior frontal sulcus and left middle frontal gyrus) regions. Present findings provide functional data supporting the hypothesis that modafinil can modulate the cortico-cerebellar connectivity of the aging brain.",
keywords = "Aging, Cognitive enhancing drugs, Connectivity, Dopamine, Eigenvector centrality, Graph theory, Resting state fMRI",
author = "Miriam Punzi and Tommaso Gili and Laura Petrosini and Carlo Caltagirone and Gianfranco Spalletta and Sensi, {Stefano L.}",
year = "2017",
month = "3",
day = "30",
doi = "10.3389/fnagi.2017.00085",
language = "English",
volume = "9",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Research Foundation",
number = "MAR",

}

TY - JOUR

T1 - Modafinil-induced changes in functional connectivity in the cortex and cerebellum of healthy elderly subjects

AU - Punzi, Miriam

AU - Gili, Tommaso

AU - Petrosini, Laura

AU - Caltagirone, Carlo

AU - Spalletta, Gianfranco

AU - Sensi, Stefano L.

PY - 2017/3/30

Y1 - 2017/3/30

N2 - In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent. To that aim, participants (n = 24) were investigated with resting state functional Magnetic Resonance Imaging (rs-fMRI) before and after the administration of a single dose (100 mg) of modafinil. Effects were compared to age and size-matched placebo group. Rs-fMRI effects were assessed, employing a graph-based approach and Eigenvector Centrality (EC) analysis, by taking in account topological changes occurring in functional brain networks. The main finding of the study is that modafinil promotes enhanced centrality, a measure of the importance of nodes within functional networks, of the bilateral primary visual (V1) cortex. EC analysis also revealed that modafinil-treated subjects show increased functional connectivity between the V1 and specific cerebellar (Crus I, Crus II, VIIIa lobule) and frontal (right inferior frontal sulcus and left middle frontal gyrus) regions. Present findings provide functional data supporting the hypothesis that modafinil can modulate the cortico-cerebellar connectivity of the aging brain.

AB - In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent. To that aim, participants (n = 24) were investigated with resting state functional Magnetic Resonance Imaging (rs-fMRI) before and after the administration of a single dose (100 mg) of modafinil. Effects were compared to age and size-matched placebo group. Rs-fMRI effects were assessed, employing a graph-based approach and Eigenvector Centrality (EC) analysis, by taking in account topological changes occurring in functional brain networks. The main finding of the study is that modafinil promotes enhanced centrality, a measure of the importance of nodes within functional networks, of the bilateral primary visual (V1) cortex. EC analysis also revealed that modafinil-treated subjects show increased functional connectivity between the V1 and specific cerebellar (Crus I, Crus II, VIIIa lobule) and frontal (right inferior frontal sulcus and left middle frontal gyrus) regions. Present findings provide functional data supporting the hypothesis that modafinil can modulate the cortico-cerebellar connectivity of the aging brain.

KW - Aging

KW - Cognitive enhancing drugs

KW - Connectivity

KW - Dopamine

KW - Eigenvector centrality

KW - Graph theory

KW - Resting state fMRI

UR - http://www.scopus.com/inward/record.url?scp=85017386181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017386181&partnerID=8YFLogxK

U2 - 10.3389/fnagi.2017.00085

DO - 10.3389/fnagi.2017.00085

M3 - Article

AN - SCOPUS:85017386181

VL - 9

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

IS - MAR

M1 - 85

ER -