Model-based assessment of baroreflex and cardiopulmonary couplings during graded head-up tilt

Alberto Porta, Tito Bassani, Vlasta Bari, Eleonora Tobaldini, Anielle C M Takahashi, Aparecida M. Catai, Nicola Montano

Research output: Contribution to journalArticlepeer-review


We propose a multivariate dynamical adjustment (MDA) modeling approach to assess the strength of baroreflex and cardiopulmonary couplings from spontaneous cardiovascular variabilities. Open loop MDA (OLMDA) and closed loop MDA (CLMDA) models were compared. The coupling strength was assessed during progressive sympathetic activation induced by graded head-up tilt. Both OLMDA and CLMDA models suggested that baroreflex coupling progressively increased with tilt table inclination. Only CLMDA model indicated that cardiopulmonary coupling due to the direct link from respiration to heart period gradually decreased with tilt table angles, while that due to the indirect link mediated by systolic arterial pressure progressively increased.

Original languageEnglish
Pages (from-to)298-305
Number of pages8
JournalComputers in Biology and Medicine
Issue number3
Publication statusPublished - Mar 2012


  • Autonomic nervous system
  • Baroreflex
  • Cardiopulmonary interactions
  • Cardiovascular control
  • Causal coupling
  • Modeling

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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