Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1β/IL-1RI complex

Rita Casadio, Elisabetta Frigimelica, Paola Bossù, Detlef Neumann, Michael U. Martin, Aldo Tagliabue, Diana Boraschi

Research output: Contribution to journalArticle

Abstract

A preliminary model has been calculated for the activating interaction of the interleukin 1 receptor (IL-1R) accessory protein IL-1RAcP with the ligand/receptor complex IL-1β/IL-1RI. First, IL-1RAcP was modeled on the crystal structure of IL-1RI bound to IL-1β. Then, the IL-1RAcP model was docked using specific programs to the crystal structure of the IL-1β/IL-1RI complex. Two types of models were predicted, with comparable probability. Experimental data obtained with the use of IL-1β peptides and antibodies, and with mutated IL-1β proteins, support the BACK model, in which IL-1RAcP establishes contacts with the back of IL-1RI wrapped around IL-1β.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalFEBS Letters
Volume499
Issue number1-2
DOIs
Publication statusPublished - Jun 15 2001

Keywords

  • Accessory protein
  • Interleukin 1
  • Molecular modeling
  • Receptor chain

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Casadio, R., Frigimelica, E., Bossù, P., Neumann, D., Martin, M. U., Tagliabue, A., & Boraschi, D. (2001). Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1β/IL-1RI complex. FEBS Letters, 499(1-2), 65-68. https://doi.org/10.1016/S0014-5793(01)02515-7