Abstract
In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.
| Original language | English |
|---|---|
| Article number | 4204085 |
| Journal | Journal of Healthcare Engineering |
| Volume | 2017 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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ASJC Scopus subject areas
- Biotechnology
- Surgery
- Biomedical Engineering
- Health Informatics
Cite this
Model of murine ventricular cardiac tissue for in vitro kinematic-dynamic studies of electromagnetic and β-adrenergic stimulation. / Fassina, Lorenzo; Cornacchione, Marisa; Pellegrini, Manuela; Mognaschi, Maria Evelina; Gimmelli, Roberto; Isidori, Andrea Maria; Lenzi, Andrea; Magenes, Giovanni; Naro, Fabio.
In: Journal of Healthcare Engineering, Vol. 2017, 4204085, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Model of murine ventricular cardiac tissue for in vitro kinematic-dynamic studies of electromagnetic and β-adrenergic stimulation
AU - Fassina, Lorenzo
AU - Cornacchione, Marisa
AU - Pellegrini, Manuela
AU - Mognaschi, Maria Evelina
AU - Gimmelli, Roberto
AU - Isidori, Andrea Maria
AU - Lenzi, Andrea
AU - Magenes, Giovanni
AU - Naro, Fabio
PY - 2017/1/1
Y1 - 2017/1/1
N2 - In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.
AB - In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.
UR - http://www.scopus.com/inward/record.url?scp=85026897195&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026897195&partnerID=8YFLogxK
U2 - 10.1155/2017/4204085
DO - 10.1155/2017/4204085
M3 - Article
AN - SCOPUS:85026897195
VL - 2017
JO - Journal of Healthcare Engineering
JF - Journal of Healthcare Engineering
SN - 2040-2295
M1 - 4204085
ER -