Model of murine ventricular cardiac tissue for in vitro kinematic-dynamic studies of electromagnetic and β-adrenergic stimulation

Lorenzo Fassina, Marisa Cornacchione, Manuela Pellegrini, Maria Evelina Mognaschi, Roberto Gimmelli, Andrea Maria Isidori, Andrea Lenzi, Giovanni Magenes, Fabio Naro

Research output: Contribution to journalArticle

Abstract

In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.

Original languageEnglish
Article number4204085
JournalJournal of Healthcare Engineering
Volume2017
DOIs
Publication statusPublished - Jan 1 2017

ASJC Scopus subject areas

  • Biotechnology
  • Surgery
  • Biomedical Engineering
  • Health Informatics

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