Modeling and mechanobiology of cerebral aneurysms

Laura Socci, G. Pennati, D. Gastaldi, P. Vena

Research output: Contribution to journalArticle

Abstract

The purpose of this work is to review the computational models of the adaptive behavior of the cerebral vascular wall aimed at simulating aneurysm formation and enlargement. Cerebral aneurysms are localized abnormal enlargements of the intracranial arterial vessels. The origin of this Pathology is still unclear: however, aneurysm formation is thought to be the result of interplay between biomechanical properties of the vessel wall and their possible changes, such as adaptive response to mechanical stimuli. Recently, different computational approaches were suggested in the literature aiming to describe the mechanobiology of the cerebral vascular wall. Most of the computational adaptive models showed a common approach for the geometrically non-linear kinematic description of the phenomenon, whilst the constitutive laws defining the rates of growth variables may differ considerably according to the specific phenomenon considered. These studies allowed the reproduction of some peculiar aspects of aneurysm mechanobiology; however, continued interdisciplinary research is mandatory for a better understanding of the mechanisms involved in the evolution of cerebral aneurysms.

Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalJournal of Applied Biomaterials and Biomechanics
Volume6
Issue number2
Publication statusPublished - May 2008

Keywords

  • Cerebral aneurysms
  • Computational modeling
  • Growth
  • Remodeling

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

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  • Cite this

    Socci, L., Pennati, G., Gastaldi, D., & Vena, P. (2008). Modeling and mechanobiology of cerebral aneurysms. Journal of Applied Biomaterials and Biomechanics, 6(2), 63-71.