Modeling, design and synthesis of new heteroaryl ethylenes active against the MCF-7 breast cancer cell-line

Vincenza Barresi, Carmela Bonaccorso, Giuseppe Consiglio, Laura Goracci, Nicolò Musso, Giuseppe Musumarra, Cristina Satriano, Cosimo G. Fortuna

Research output: Contribution to journalArticle

Abstract

A dataset of 50 compounds was used to generate a QSAR model and to design 9 new heteroaryl ethylenes. These compounds were synthesized, tested in vitro and a significant agreement with in silico predictions observed. Studies using Laser Scanning Confocal Microscopy pointed out that the compounds may act by different mechanisms.

Original languageEnglish
Pages (from-to)2426-2429
Number of pages4
JournalMolecular BioSystems
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2013

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Medicine(all)

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    Barresi, V., Bonaccorso, C., Consiglio, G., Goracci, L., Musso, N., Musumarra, G., Satriano, C., & Fortuna, C. G. (2013). Modeling, design and synthesis of new heteroaryl ethylenes active against the MCF-7 breast cancer cell-line. Molecular BioSystems, 9(10), 2426-2429. https://doi.org/10.1039/c3mb70151d