Modeling of biological and medical systems: a systemic strategy

Piero Mussio, Maurizio Pietrogrande, Francesco Brambilla, Carmelo Caserta, Alberto Cefalo, Mariateresa Randetti, Paolo Bottoni, Nicola Dioguardi

Research output: Contribution to journalArticlepeer-review


A strategy in the frame of General System Theory is proposed for the study of biological systems for medical purposes. Its definition and use requires in each experiment the collaboration between physician and system scientists and hence the definition of a common language, by which the real system under study is described. The strategy is based on three intermingled steps: first an ingenuous model is proposed, gathering all the medical knowledge about the studied system, organized within an informal frame derived from the state space approach. Next, a functional model is derived, enlightening the organization of the relations in the medical model. Finally, this organization is formalized by the most suitable algebraic tools, which are thereafter translated into APL programs. This last version is used for simulation, which is exploited not only as a tool to describe and make provisions on the dynamics of the models, but also to deepen and improve the knowledge about the observed system.

Original languageEnglish
Pages (from-to)31-43
Number of pages13
Issue number1
Publication statusPublished - 1991


  • Biological systems
  • Dynamic simulation
  • Modeling
  • State space approach

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Drug Discovery


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