Abstract
A strategy in the frame of General System Theory is proposed for the study of biological systems for medical purposes. Its definition and use requires in each experiment the collaboration between physician and system scientists and hence the definition of a common language, by which the real system under study is described. The strategy is based on three intermingled steps: first an ingenuous model is proposed, gathering all the medical knowledge about the studied system, organized within an informal frame derived from the state space approach. Next, a functional model is derived, enlightening the organization of the relations in the medical model. Finally, this organization is formalized by the most suitable algebraic tools, which are thereafter translated into APL programs. This last version is used for simulation, which is exploited not only as a tool to describe and make provisions on the dynamics of the models, but also to deepen and improve the knowledge about the observed system.
| Original language | English |
|---|---|
| Pages (from-to) | 31-43 |
| Number of pages | 13 |
| Journal | BioSystems |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Biological systems
- Dynamic simulation
- Modeling
- State space approach
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Biotechnology
- Drug Discovery
Cite this
Modeling of biological and medical systems : a systemic strategy. / Mussio, Piero; Pietrogrande, Maurizio; Brambilla, Francesco; Caserta, Carmelo; Cefalo, Alberto; Randetti, Mariateresa; Bottoni, Paolo; Dioguardi, Nicola.
In: BioSystems, Vol. 26, No. 1, 1991, p. 31-43.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modeling of biological and medical systems
T2 - a systemic strategy
AU - Mussio, Piero
AU - Pietrogrande, Maurizio
AU - Brambilla, Francesco
AU - Caserta, Carmelo
AU - Cefalo, Alberto
AU - Randetti, Mariateresa
AU - Bottoni, Paolo
AU - Dioguardi, Nicola
PY - 1991
Y1 - 1991
N2 - A strategy in the frame of General System Theory is proposed for the study of biological systems for medical purposes. Its definition and use requires in each experiment the collaboration between physician and system scientists and hence the definition of a common language, by which the real system under study is described. The strategy is based on three intermingled steps: first an ingenuous model is proposed, gathering all the medical knowledge about the studied system, organized within an informal frame derived from the state space approach. Next, a functional model is derived, enlightening the organization of the relations in the medical model. Finally, this organization is formalized by the most suitable algebraic tools, which are thereafter translated into APL programs. This last version is used for simulation, which is exploited not only as a tool to describe and make provisions on the dynamics of the models, but also to deepen and improve the knowledge about the observed system.
AB - A strategy in the frame of General System Theory is proposed for the study of biological systems for medical purposes. Its definition and use requires in each experiment the collaboration between physician and system scientists and hence the definition of a common language, by which the real system under study is described. The strategy is based on three intermingled steps: first an ingenuous model is proposed, gathering all the medical knowledge about the studied system, organized within an informal frame derived from the state space approach. Next, a functional model is derived, enlightening the organization of the relations in the medical model. Finally, this organization is formalized by the most suitable algebraic tools, which are thereafter translated into APL programs. This last version is used for simulation, which is exploited not only as a tool to describe and make provisions on the dynamics of the models, but also to deepen and improve the knowledge about the observed system.
KW - Biological systems
KW - Dynamic simulation
KW - Modeling
KW - State space approach
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UR - http://www.scopus.com/inward/citedby.url?scp=0025933211&partnerID=8YFLogxK
U2 - 10.1016/0303-2647(91)90035-J
DO - 10.1016/0303-2647(91)90035-J
M3 - Article
C2 - 1760533
AN - SCOPUS:0025933211
VL - 26
SP - 31
EP - 43
JO - BioSystems
JF - BioSystems
SN - 0303-2647
IS - 1
ER -