Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

Egidio D'Angelo; Thierry Nieus; Michele Bezzi; Angelo Arleo; Olivier J M D Coenen

Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

Egidio D'Angelo, Thierry Nieus, Michele Bezzi, Angelo Arleo, Olivier J M D Coenen

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).

Original language	English
Title of host publication	Lecture Notes in Computer Science
Editors	J. Cabestany, A. Prieto, F. Sandoval
Pages	107-114
Number of pages	8
Volume	3512
Publication status	Published - 2005
Event	8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems - Vilanova i la Geltru, Spain Duration: Jun 8 2005 → Jun 10 2005

Other

Other	8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems
Country/Territory	Spain
City	Vilanova i la Geltru
Period	6/8/05 → 6/10/05

ASJC Scopus subject areas

Computer Science (miscellaneous)

Cite this

D'Angelo, E, Nieus, T, Bezzi, M, Arleo, A & Coenen, OJMD 2005, Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum. in J Cabestany, A Prieto & F Sandoval (eds), Lecture Notes in Computer Science. vol. 3512, pp. 107-114, 8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems, Vilanova i la Geltru, Spain, 6/8/05.

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title = "Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum",

abstract = "Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).",

author = "Egidio D'Angelo and Thierry Nieus and Michele Bezzi and Angelo Arleo and Coenen, {Olivier J M D}",

year = "2005",

language = "English",

volume = "3512",

pages = "107--114",

editor = "J. Cabestany and A. Prieto and F. Sandoval",

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note = "8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems ; Conference date: 08-06-2005 Through 10-06-2005",

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T1 - Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

AU - D'Angelo, Egidio

AU - Nieus, Thierry

AU - Bezzi, Michele

AU - Arleo, Angelo

AU - Coenen, Olivier J M D

PY - 2005

Y1 - 2005

N2 - Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).

AB - Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).

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M3 - Conference contribution

AN - SCOPUS:25144453342

VL - 3512

SP - 107

EP - 114

BT - Lecture Notes in Computer Science

A2 - Cabestany, J.

A2 - Prieto, A.

A2 - Sandoval, F.

T2 - 8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems

Y2 - 8 June 2005 through 10 June 2005

ER -

Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

Abstract

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ASJC Scopus subject areas

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