Abstract
Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).
Original language | English |
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Title of host publication | Lecture Notes in Computer Science |
Editors | J. Cabestany, A. Prieto, F. Sandoval |
Pages | 107-114 |
Number of pages | 8 |
Volume | 3512 |
Publication status | Published - 2005 |
Event | 8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems - Vilanova i la Geltru, Spain Duration: Jun 8 2005 → Jun 10 2005 |
Other
Other | 8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems |
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Country/Territory | Spain |
City | Vilanova i la Geltru |
Period | 6/8/05 → 6/10/05 |
ASJC Scopus subject areas
- Computer Science (miscellaneous)