Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

Egidio D'Angelo; Thierry Nieus; Michele Bezzi; Angelo Arleo; Olivier J M D Coenen

Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

Egidio D'Angelo, Thierry Nieus, Michele Bezzi, Angelo Arleo, Olivier J M D Coenen

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).

Original language	English
Title of host publication	Lecture Notes in Computer Science
Editors	J. Cabestany, A. Prieto, F. Sandoval
Pages	107-114
Number of pages	8
Volume	3512
Publication status	Published - 2005
Event	8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems - Vilanova i la Geltru, Spain Duration: Jun 8 2005 → Jun 10 2005

Other

Other	8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems
Country/Territory	Spain
City	Vilanova i la Geltru
Period	6/8/05 → 6/10/05

ASJC Scopus subject areas

Computer Science (miscellaneous)

Cite this

Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum. / D'Angelo, Egidio; Nieus, Thierry; Bezzi, Michele; Arleo, Angelo; Coenen, Olivier J M D.

Lecture Notes in Computer Science. ed. / J. Cabestany; A. Prieto; F. Sandoval. Vol. 3512 2005. p. 107-114.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

D'Angelo, E, Nieus, T, Bezzi, M, Arleo, A & Coenen, OJMD 2005, Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum. in J Cabestany, A Prieto & F Sandoval (eds), Lecture Notes in Computer Science. vol. 3512, pp. 107-114, 8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems, Vilanova i la Geltru, Spain, 6/8/05.

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abstract = "Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).",

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editor = "J. Cabestany and A. Prieto and F. Sandoval",

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T1 - Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

AU - D'Angelo, Egidio

AU - Nieus, Thierry

AU - Bezzi, Michele

AU - Arleo, Angelo

AU - Coenen, Olivier J M D

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N2 - Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).

AB - Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber - granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).

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A2 - Cabestany, J.

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Y2 - 8 June 2005 through 10 June 2005

ER -

Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum

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