Modeling the cerebellar microcircuit: New strategies for a long-standing issue

Egidio D’Angelo, Alberto Antonietti, Stefano Casali, Claudia Casellato, Jesus A. Garrido, Niceto Rafael Luque, Lisa Mapelli, Stefano Masoli, Alessandra Pedrocchi, Francesca Prestori, Martina Francesca Rizza, Eduardo Ros

Research output: Contribution to journalReview article

Abstract

The cerebellar microcircuit has been the work bench for theoretical and computational modeling since the beginning of neuroscientific research. The regular neural architecture of the cerebellum inspired different solutions to the long-standing issue of how its circuitry could control motor learning and coordination. Originally, the cerebellar network was modeled using a statistical-topological approach that was later extended by considering the geometrical organization of local microcircuits. However, with the advancement in anatomical and physiological investigations, new discoveries have revealed an unexpected richness of connections, neuronal dynamics and plasticity, calling for a change in modeling strategies, so as to include the multitude of elementary aspects of the network into an integrated and easily updatable computational framework. Recently, biophysically accurate “realistic” models using a bottom-up strategy accounted for both detailed connectivity and neuronal non-linear membrane dynamics. In this perspective review, we will consider the state of the art and discuss how these initial efforts could be further improved. Moreover, we will consider how embodied neurorobotic models including spiking cerebellar networks could help explaining the role and interplay of distributed forms of plasticity. We envisage that realistic modeling, combined with closed-loop simulations, will help to capture the essence of cerebellar computations and could eventually be applied to neurological diseases and neurorobotic control systems.

Original languageEnglish
Article number176
JournalFrontiers in Cellular Neuroscience
Volume10
Issue numberJULY
DOIs
Publication statusPublished - Jul 8 2016

Keywords

  • Cellular neurophysiology
  • Cerebellum
  • Computational modeling
  • Microcircuit
  • Motor learning
  • Neural plasticity
  • Neurorobotics
  • Spiking neural network

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    D’Angelo, E., Antonietti, A., Casali, S., Casellato, C., Garrido, J. A., Luque, N. R., Mapelli, L., Masoli, S., Pedrocchi, A., Prestori, F., Rizza, M. F., & Ros, E. (2016). Modeling the cerebellar microcircuit: New strategies for a long-standing issue. Frontiers in Cellular Neuroscience, 10(JULY), [176]. https://doi.org/10.3389/fncel.2016.00176