Modeling the contribution of neuron-astrocyte cross talk to slow blood oxygenation level-dependent signal oscillations

Mauro di Nuzzo, Tommaso Gili, Bruno Maraviglia, Federico Giove

Research output: Contribution to journalArticle

Abstract

A consistent and prominent feature of brain functional magnetic resonance imaging (fMRI) data is the presence of low-frequency (+ signaling. Specifically, neurotransmission induces pulses of Ca2 + concentration in astrocytes, resulting in increased cerebral perfusion and neuroactive transmitter release by these cells (i.e., gliotransmission), which in turn stimulates neuronal activity. Noticeably, the level of neuron-astrocyte cross talk regulates the periodic behavior of the Ca2 + wave-induced BOLD fluctuations. Our results suggest that the spontaneous ongoing activity of neuroglial networks is a potential source of the observed slow fMRI signal oscillations.

Original languageEnglish
Pages (from-to)3010-3018
Number of pages9
JournalJournal of Neurophysiology
Volume106
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Astrocytes
  • Brain resting state
  • Calcium waves

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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