Abstract
A consistent and prominent feature of brain functional magnetic resonance imaging (fMRI) data is the presence of low-frequency (+ signaling. Specifically, neurotransmission induces pulses of Ca2 + concentration in astrocytes, resulting in increased cerebral perfusion and neuroactive transmitter release by these cells (i.e., gliotransmission), which in turn stimulates neuronal activity. Noticeably, the level of neuron-astrocyte cross talk regulates the periodic behavior of the Ca2 + wave-induced BOLD fluctuations. Our results suggest that the spontaneous ongoing activity of neuroglial networks is a potential source of the observed slow fMRI signal oscillations.
Original language | English |
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Pages (from-to) | 3010-3018 |
Number of pages | 9 |
Journal | Journal of Neurophysiology |
Volume | 106 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2011 |
Keywords
- Astrocytes
- Brain resting state
- Calcium waves
ASJC Scopus subject areas
- Physiology
- Neuroscience(all)