Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems

Marta Trevisan, Alessandro Sinigaglia, Giovanna Desole, Alessandro Berto, Monia Pacenti, Giorgio Palù, Luisa Barzon

Research output: Contribution to journalArticlepeer-review

Abstract

The recent biotechnology breakthrough of cell reprogramming and generation of nduced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study he mechanisms of human diseases and to test new drugs, can be exploited to generate atient-specific models for the investigation of host–pathogen interactions and to develop ew antimicrobial and antiviral therapies. Applications of iPSC technology to the study f viral infections in humans have included in vitro modeling of viral infections of neural, iver, and cardiac cells; modeling of human genetic susceptibility to severe viral infectious iseases, such as encephalitis and severe influenza; genetic engineering and genome editing f patient-specific iPSC-derived cells to confer antiviral resistance.

Original languageEnglish
Pages (from-to)3835-3856
Number of pages22
JournalViruses
Volume7
Issue number7
DOIs
Publication statusPublished - Jul 13 2015

Keywords

  • Antiviral resistance
  • CRISPR/Cas9
  • Ersonalized therapy
  • Genetic susceptibility
  • Genome editing
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Human induced pluripotent stem cells
  • Patient-specific isease model
  • Viral infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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