Modelling approaches for angiogenesis

Research output: Contribution to journalArticle

Abstract

The development of a functional vasculature within a tumour is a requisite for its growth and progression. This fact has led to the design of therapies directed toward the tumour vasculature, aiming either to prevent the formation of new vessels (anti-angiogenic) or to damage existing vessels (vascular targeting). The development of agents with different mechanisms of action requires powerful preclinical models for the analysis and optimization of these therapies. This review concerns 'classical' assays of angiogenesis in vitro and in vivo, recent approaches to target identification (analysis of gene and protein expression), and the study of morphological and functional changes in the vasculature in vivo (imaging techniques). It mainly describes assays designed for anti-angiogenic compounds, indicating, where possible, their application to the study of vascular-targeting agents.

Original languageEnglish
Pages (from-to)881-889
Number of pages9
JournalEuropean Journal of Cancer
Volume40
Issue number6
DOIs
Publication statusPublished - Apr 2004

Keywords

  • Angiogenesis
  • Angiogenesis inhibitors
  • Endothelial cells
  • Imaging
  • Preclinical assays
  • Tumour vasculature
  • Vascular-targeting agents

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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