Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies

M. Rota, F. Rumi, V. Bagnardi, L. Dal Maso, A. Zucchetto, F. Levi, C. La Vecchia, A. Tavani

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective To quantify the relation between body mass index (BMI) and endometrial cancer risk, and to describe the shape of such a relation. Design Pooled analysis of three hospital-based case-control studies. Setting Italy and Switzerland. Population A total of 1449 women with endometrial cancer and 3811 controls. Methods Multivariate odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from logistic regression models. The shape of the relation was determined using a class of flexible regression models. Main outcome measure The relation of BMI with endometrial cancer. Results Compared with women with BMI 18.5 to 2, the odds ratio was 5.73 (95% CI 4.28-7.68) for women with a BMI ≥35 kg/m2. The odds ratios were 1.10 (95% CI 1.09-1.12) and 1.63 (95% CI 1.52-1.75) respectively for an increment of BMI of 1 and 5 units. The relation was stronger in never-users of oral contraceptives (OR 3.35, 95% CI 2.78-4.03, for BMI ≥30 versus 2) than in users (OR 1.22, 95% CI 0.56-2.67), and in women with diabetes (OR 8.10, 95% CI 4.10-16.01, for BMI ≥30 versus 2) than in those without diabetes (OR 2.95, 95% CI 2.44-3.56). The relation was best fitted by a cubic model, although after the exclusion of the 5% upper and lower tails, it was best fitted by a linear model. Conclusions The results of this study confirm a role of elevated BMI in the aetiology of endometrial cancer and suggest that the risk in obese women increases in a cubic nonlinear fashion. The relation was stronger in never-users of oral contraceptives and in women with diabetes. Tweetable Abstract Risk of endometrial cancer increases with elevated body weight in a cubic nonlinear fashion.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume123
Issue number2
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Endometrial Neoplasms
Case-Control Studies
Body Mass Index
Confidence Intervals
Odds Ratio
Oral Contraceptives
Logistic Models
Switzerland
Italy
Linear Models
Body Weight
Outcome Assessment (Health Care)
Population

Keywords

  • Body mass index
  • endometrial cancer
  • fractional polynomial
  • hospital-based case-control studies
  • obesity
  • overweight

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies. / Rota, M.; Rumi, F.; Bagnardi, V.; Dal Maso, L.; Zucchetto, A.; Levi, F.; La Vecchia, C.; Tavani, A.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 123, No. 2, 01.01.2016, p. 285-292.

Research output: Contribution to journalArticle

@article{5fae9597b0e34a2a9aee674245769553,
title = "Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies",
abstract = "Objective To quantify the relation between body mass index (BMI) and endometrial cancer risk, and to describe the shape of such a relation. Design Pooled analysis of three hospital-based case-control studies. Setting Italy and Switzerland. Population A total of 1449 women with endometrial cancer and 3811 controls. Methods Multivariate odds ratios (OR) and 95{\%} confidence intervals (95{\%} CI) were obtained from logistic regression models. The shape of the relation was determined using a class of flexible regression models. Main outcome measure The relation of BMI with endometrial cancer. Results Compared with women with BMI 18.5 to 2, the odds ratio was 5.73 (95{\%} CI 4.28-7.68) for women with a BMI ≥35 kg/m2. The odds ratios were 1.10 (95{\%} CI 1.09-1.12) and 1.63 (95{\%} CI 1.52-1.75) respectively for an increment of BMI of 1 and 5 units. The relation was stronger in never-users of oral contraceptives (OR 3.35, 95{\%} CI 2.78-4.03, for BMI ≥30 versus 2) than in users (OR 1.22, 95{\%} CI 0.56-2.67), and in women with diabetes (OR 8.10, 95{\%} CI 4.10-16.01, for BMI ≥30 versus 2) than in those without diabetes (OR 2.95, 95{\%} CI 2.44-3.56). The relation was best fitted by a cubic model, although after the exclusion of the 5{\%} upper and lower tails, it was best fitted by a linear model. Conclusions The results of this study confirm a role of elevated BMI in the aetiology of endometrial cancer and suggest that the risk in obese women increases in a cubic nonlinear fashion. The relation was stronger in never-users of oral contraceptives and in women with diabetes. Tweetable Abstract Risk of endometrial cancer increases with elevated body weight in a cubic nonlinear fashion.",
keywords = "Body mass index, endometrial cancer, fractional polynomial, hospital-based case-control studies, obesity, overweight",
author = "M. Rota and F. Rumi and V. Bagnardi and {Dal Maso}, L. and A. Zucchetto and F. Levi and {La Vecchia}, C. and A. Tavani",
year = "2016",
month = "1",
day = "1",
doi = "10.1111/1471-0528.13717",
language = "English",
volume = "123",
pages = "285--292",
journal = "BJOG: An International Journal of Obstetrics and Gynaecology",
issn = "1470-0328",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies

AU - Rota, M.

AU - Rumi, F.

AU - Bagnardi, V.

AU - Dal Maso, L.

AU - Zucchetto, A.

AU - Levi, F.

AU - La Vecchia, C.

AU - Tavani, A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective To quantify the relation between body mass index (BMI) and endometrial cancer risk, and to describe the shape of such a relation. Design Pooled analysis of three hospital-based case-control studies. Setting Italy and Switzerland. Population A total of 1449 women with endometrial cancer and 3811 controls. Methods Multivariate odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from logistic regression models. The shape of the relation was determined using a class of flexible regression models. Main outcome measure The relation of BMI with endometrial cancer. Results Compared with women with BMI 18.5 to 2, the odds ratio was 5.73 (95% CI 4.28-7.68) for women with a BMI ≥35 kg/m2. The odds ratios were 1.10 (95% CI 1.09-1.12) and 1.63 (95% CI 1.52-1.75) respectively for an increment of BMI of 1 and 5 units. The relation was stronger in never-users of oral contraceptives (OR 3.35, 95% CI 2.78-4.03, for BMI ≥30 versus 2) than in users (OR 1.22, 95% CI 0.56-2.67), and in women with diabetes (OR 8.10, 95% CI 4.10-16.01, for BMI ≥30 versus 2) than in those without diabetes (OR 2.95, 95% CI 2.44-3.56). The relation was best fitted by a cubic model, although after the exclusion of the 5% upper and lower tails, it was best fitted by a linear model. Conclusions The results of this study confirm a role of elevated BMI in the aetiology of endometrial cancer and suggest that the risk in obese women increases in a cubic nonlinear fashion. The relation was stronger in never-users of oral contraceptives and in women with diabetes. Tweetable Abstract Risk of endometrial cancer increases with elevated body weight in a cubic nonlinear fashion.

AB - Objective To quantify the relation between body mass index (BMI) and endometrial cancer risk, and to describe the shape of such a relation. Design Pooled analysis of three hospital-based case-control studies. Setting Italy and Switzerland. Population A total of 1449 women with endometrial cancer and 3811 controls. Methods Multivariate odds ratios (OR) and 95% confidence intervals (95% CI) were obtained from logistic regression models. The shape of the relation was determined using a class of flexible regression models. Main outcome measure The relation of BMI with endometrial cancer. Results Compared with women with BMI 18.5 to 2, the odds ratio was 5.73 (95% CI 4.28-7.68) for women with a BMI ≥35 kg/m2. The odds ratios were 1.10 (95% CI 1.09-1.12) and 1.63 (95% CI 1.52-1.75) respectively for an increment of BMI of 1 and 5 units. The relation was stronger in never-users of oral contraceptives (OR 3.35, 95% CI 2.78-4.03, for BMI ≥30 versus 2) than in users (OR 1.22, 95% CI 0.56-2.67), and in women with diabetes (OR 8.10, 95% CI 4.10-16.01, for BMI ≥30 versus 2) than in those without diabetes (OR 2.95, 95% CI 2.44-3.56). The relation was best fitted by a cubic model, although after the exclusion of the 5% upper and lower tails, it was best fitted by a linear model. Conclusions The results of this study confirm a role of elevated BMI in the aetiology of endometrial cancer and suggest that the risk in obese women increases in a cubic nonlinear fashion. The relation was stronger in never-users of oral contraceptives and in women with diabetes. Tweetable Abstract Risk of endometrial cancer increases with elevated body weight in a cubic nonlinear fashion.

KW - Body mass index

KW - endometrial cancer

KW - fractional polynomial

KW - hospital-based case-control studies

KW - obesity

KW - overweight

UR - http://www.scopus.com/inward/record.url?scp=84952864038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952864038&partnerID=8YFLogxK

U2 - 10.1111/1471-0528.13717

DO - 10.1111/1471-0528.13717

M3 - Article

C2 - 26541752

AN - SCOPUS:84952864038

VL - 123

SP - 285

EP - 292

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 2

ER -