Modelling the effects of ongoing alpha activity on visual perception: The oscillation-based probability of response

Agnese Zazio, Marco Schreiber, Carlo Miniussi, Marta Bortoletto

Research output: Contribution to journalReview articlepeer-review

Abstract

Substantial evidence has shown that ongoing neural activity significantly contributes to how the brain responds to upcoming stimuli. In visual perception, a considerable portion of trial-to-trial variability can be accounted for by prestimulus magneto/electroencephalographic (M/EEG) alpha oscillations, which play an inhibitory function by means of cross-frequency interactions with gamma-band oscillations. Despite the fundamental theories on the role of oscillations in perception and cognition, the current literature lacks a clear theorization of the neural mechanisms underlying the effects of prestimulus activity, including electrophysiological phenomena at different scales (e.g., local field potentials and macro-scale M/EEG). Here, we present a model called the oscillation-based probability of response (OPR), which directly assesses the link between meso-scale neural mechanisms, macro-scale M/EEG, and behavioural outcome. The OPR includes distinct meso-scale mechanisms through which alpha oscillations modulate M/EEG gamma activity, namely, by decreasing a) the amplitude and/or b) neural synchronization of gamma oscillations. Crucially, the OPR makes specific predictions on the effects of these mechanisms on visual perception, as assessed through the psychometric function. significance statement: The oscillation-based probability of response (OPR) is grounded on a psychophysical approach focusing on the psychometric function estimation and may be highly informative in the study of ongoing brain activity, because it provides a tool for distinguishing different neural mechanisms of alpha-driven modulation of sensory processing.

Original languageEnglish
Pages (from-to)242-253
Number of pages12
JournalNeuroscience and Biobehavioral Reviews
Volume112
DOIs
Publication statusPublished - May 2020

Keywords

  • Alpha
  • Cross-Frequency
  • Gamma
  • Neural oscillations
  • Perception
  • Prestimulus
  • Psychometric function

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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