Models of glucose disposal: estimation of glucose effectiveness with an optimal protocol

F. Bettini, A. Caumo, R. Rizza, C. Cobelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study we developed models to describe the effect of glucose on its own disposal (glucose effectiveness) under nonsteady state conditions. The data base consisted of experiments during which glucose concentration exhibited a meal-like profile while insulin was maintained at the basal level. This optimal protocol allowed us to rule out the possibly confounding effect of hyperinsulinemia on the assessment of glucose effectiveness. Five models were formulated. All were based upon a mono-compartmental description of glucose kinetics but used different descriptions of the rate of glucose uptake as a function of glucose concentration. The two models which appeared superior in terms of model fit and precision of the parameter estimates incorporate a nonlinear, saturative effect of hyperglycemia and a delay between glucose elevation in plasma and its effect on glucose uptake.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages1828-1829
Number of pages2
Volume5
Publication statusPublished - 1996
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: Oct 31 1996Nov 3 1996

Other

OtherProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)
CityAmsterdam, Neth
Period10/31/9611/3/96

ASJC Scopus subject areas

  • Bioengineering

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