TY - JOUR
T1 - Moderate Alcohol Consumption Is Associated With Lower Risk for Heart Failure But Not Atrial Fibrillation
AU - Di Castelnuovo, Augusto
AU - Costanzo, Simona
AU - Bonaccio, Marialaura
AU - Rago, Livia
AU - De Curtis, Amalia
AU - Persichillo, Mariarosaria
AU - Bracone, Francesca
AU - Olivieri, Marco
AU - Cerletti, Chiara
AU - Donati, Maria Benedetta
AU - de Gaetano, Giovanni
AU - Iacoviello, Licia
AU - Iacoviello, Licia
AU - Donati, Maria Benedetta
AU - de Gaetano, Giovanni
AU - Vermylen, Jos
AU - De Paula Carrasco, Ignacio
AU - Giampaoli, Simona
AU - Spagnuolo, Antonio
AU - Assanelli, Deodato
AU - Centritto, Vincenzo
AU - Spagnuolo, Pasquale
AU - Staniscia, Dante
AU - Zito, Francesco
AU - Bonanni, Americo
AU - Cerletti, Chiara
AU - De Curtis, Amalia
AU - Di Castelnuovo, Augusto
AU - Iacoviello, Licia
AU - Lorenzet, Roberto
AU - Di Castelnuovo, Augusto
AU - Bonaccio, Marialaura
AU - Costanzo, Simona
AU - Gianfagna, Francesco
AU - De Curtis, Amalia
AU - Marracino, Federico
AU - Bonaccio, Marialaura
AU - Gianfagna, Francesco
AU - Persichillo, Mariarosaria
AU - Arcari, Antonella
AU - Costanzo, Simona
AU - Marracino, Federico
AU - Cugino, Daniela
AU - Gianfagna, Francesco
AU - Costanzo, Simona
AU - Costanzo, Simona
AU - Costanzo, Simona
AU - De Curtis, Amalia
AU - Iacoviello, Licia
AU - Persichillo, Mariarosaria
AU - Moli-sani Investigators
AU - Moli-sani Investigators
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Objectives The aim of this study was to assess the hypothesis that alcohol consumption is associated with onset of atrial fibrillation (AF) and/or heart failure (HF). Background The connection between ethanol intake and AF or HF remains controversial. Methods The study population was 22,824 AF- or HF-free subjects (48% men, age ≥35 years) randomly recruited from the general population included in the Moli-sani study, for whom complete data on HF, AF, and alcohol consumption were available. The cohort was followed up to December 31, 2015, for a median of 8.2 years (183,912 person-years). Incident cases were identified through linkage to the Molise regional archive of hospital discharges. Hazard ratios were calculated using Cox proportional hazard models and cubic spline regression. Results A total of 943 incident cases of HF and 554 of AF were identified. In comparison with never drinkers, both former and occasional drinkers showed comparable risk for developing HF. Drinking alcohol in the range of 1 to 4 drinks/day was associated with a lower risk for HF, with a 22% maximum risk reduction at 20 g/day, independent of common confounders. In contrast, no association of alcohol consumption with onset of AF was observed. Very similar results were obtained after restriction of the analyses to regular or only wine drinkers or according to sex, age, social status, or adherence to the Mediterranean diet. Conclusions Consumption of alcohol in moderation was associated with a lower incidence of HF but not with development of AF.
AB - Objectives The aim of this study was to assess the hypothesis that alcohol consumption is associated with onset of atrial fibrillation (AF) and/or heart failure (HF). Background The connection between ethanol intake and AF or HF remains controversial. Methods The study population was 22,824 AF- or HF-free subjects (48% men, age ≥35 years) randomly recruited from the general population included in the Moli-sani study, for whom complete data on HF, AF, and alcohol consumption were available. The cohort was followed up to December 31, 2015, for a median of 8.2 years (183,912 person-years). Incident cases were identified through linkage to the Molise regional archive of hospital discharges. Hazard ratios were calculated using Cox proportional hazard models and cubic spline regression. Results A total of 943 incident cases of HF and 554 of AF were identified. In comparison with never drinkers, both former and occasional drinkers showed comparable risk for developing HF. Drinking alcohol in the range of 1 to 4 drinks/day was associated with a lower risk for HF, with a 22% maximum risk reduction at 20 g/day, independent of common confounders. In contrast, no association of alcohol consumption with onset of AF was observed. Very similar results were obtained after restriction of the analyses to regular or only wine drinkers or according to sex, age, social status, or adherence to the Mediterranean diet. Conclusions Consumption of alcohol in moderation was associated with a lower incidence of HF but not with development of AF.
KW - alcohol consumption
KW - atrial fibrillation
KW - heart failure
UR - http://www.scopus.com/inward/record.url?scp=85030848548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030848548&partnerID=8YFLogxK
U2 - 10.1016/j.jchf.2017.08.017
DO - 10.1016/j.jchf.2017.08.017
M3 - Article
AN - SCOPUS:85030848548
VL - 5
SP - 837
EP - 844
JO - JACC: Heart Failure
JF - JACC: Heart Failure
SN - 2213-1779
IS - 11
ER -