Moderate exercise training induces ros-related adaptations to skeletal muscles

P. M. Abruzzo, F. Esposito, C. Marchionni, S. Di Tullio, S. Belia, S. Fulle, A. Veicsteinas, M. Marini

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aim of the present work was the evaluation of the effects of moderate exercise training on 2 skeletal muscles differing in fibre-type composition, Tibialis Anterior (TA) and Soleus (SOL). Fibre adaptations, including their metabolic shift and mechanisms underlying proliferation and differentiation, oxidative stress markers, antioxidant and cytoprotective molecules, activity of Ca2+-handling molecules were examined. 6 male 2-month-old rats trained on a treadmill for 1 h/day, 3 days/week, for 14 weeks, reaching 30 m/min at the end of training. 6 age-matched sedentary rats served as controls. Rats were sacrificed 24 h after the last training session. Muscle regulatory factors increased in both muscles, activating satellite cell proliferation, which led to moderate hypertrophy in SOL and to moderate hyperplasia in TA, where the upregulation of desmin and TNFR2 expression suggests that myotube formation by proliferating myoblasts is somehow delayed. Changes leading to a more oxidative metabolism together with the upregulation of a number of antioxidant enzymes occurred in TA. HSP70i protein was upregulated in both SOL and TA, while oxidative stress markers increased in SOL alone. The status of ionic channels and pumps was preserved. We suggest that the increase in ROS, known to be associated with exercise, underlies most observed results.

Original languageEnglish
Pages (from-to)676-687
Number of pages12
JournalInternational Journal of Sports Medicine
Volume34
Issue number8
DOIs
Publication statusPublished - 2013

Fingerprint

Skeletal Muscle
Exercise
Oxidative Stress
Up-Regulation
Antioxidants
Receptors, Tumor Necrosis Factor, Type II
Muscles
Desmin
Myoblasts
Skeletal Muscle Fibers
Ion Channels
Hypertrophy
Hyperplasia
Cell Proliferation
Enzymes
Proteins

Keywords

  • moderate aerobic training
  • muscle plasticity
  • oxidative stress and signaling
  • reactive oxygen species
  • slow- and fast-twitch muscles

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Medicine(all)

Cite this

Moderate exercise training induces ros-related adaptations to skeletal muscles. / Abruzzo, P. M.; Esposito, F.; Marchionni, C.; Di Tullio, S.; Belia, S.; Fulle, S.; Veicsteinas, A.; Marini, M.

In: International Journal of Sports Medicine, Vol. 34, No. 8, 2013, p. 676-687.

Research output: Contribution to journalArticle

Abruzzo, PM, Esposito, F, Marchionni, C, Di Tullio, S, Belia, S, Fulle, S, Veicsteinas, A & Marini, M 2013, 'Moderate exercise training induces ros-related adaptations to skeletal muscles', International Journal of Sports Medicine, vol. 34, no. 8, pp. 676-687. https://doi.org/10.1055/s-0032-1323782
Abruzzo, P. M. ; Esposito, F. ; Marchionni, C. ; Di Tullio, S. ; Belia, S. ; Fulle, S. ; Veicsteinas, A. ; Marini, M. / Moderate exercise training induces ros-related adaptations to skeletal muscles. In: International Journal of Sports Medicine. 2013 ; Vol. 34, No. 8. pp. 676-687.
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