Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion

Rosangela Lattanzio, Francesca Sampietro, Andrea Ramoni, Annalisa Fattorini, Rosario Brancato, Armando D'Angelo

Research output: Contribution to journalArticlepeer-review


PURPOSE: To evaluate the prevalence of moderate fasting hyperhomocysteinemia (HHcy) and postmethionine load (PML) HHcy among patients with early-onset central retinal vein occlusion (CRVO). METHODS: The prevalence of fasting HHcy and that of PML HHcy were evaluated in a consecutive series of 58 patients with CRVO who were younger than 56 years of age (mean age, 40.3 years) and in 103 controls (mean age, 39.6 years). Plasma folate, vitamin B12, and pyridoxal-5′-phosphate (PLP) levels were measured in 42 patients and 67 controls. RESULTS: Mantel-Haenszel odds ratios for CRVO patients were 3.00 (95% confidence interval [CI], 0.83-10.8) for fasting HHcy, 3.50 (95% CI, 1.07-11.4) for PML HHcy, and 3.00 (1.18-7.6) for fasting HHcy and PML HHcy in subjects with normal fasting total homocysteine (tHcy) levels. Moderate HHcy was associated with reduced plasma levels of folate and PLP (P ≤ 0.04). There was no significant dependence of fasting and PML tHcy levels on any traditional risk factor evaluated. CONCLUSIONS: Moderate HHcy is an independent risk factor for early-onset CRVO.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
Issue number1
Publication statusPublished - Jan 2006


  • Central retinal vein occlusion
  • Hypercoagulability
  • Hyperhomocysteinemia
  • Risk factors
  • Thrombophilia

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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