Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma

M. Deckert, A. Engert, W. Brück, A. J M Ferreri, J. Finke, G. Illerhaus, W. Klapper, A. Korfel, R. Küppers, M. Maarouf, M. Montesinos-Rongen, W. Paulus, U. Schlegel, H. Lassmann, O. D. Wiestler, R. Siebert, L. M. Deangelis

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL.

Original languageEnglish
Pages (from-to)1797-1807
Number of pages11
JournalLeukemia
Volume25
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • chemotherapy
  • diffuse large B-cell lymphoma
  • pathogenesis
  • primary CNS lymphoma
  • radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

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