Modern management of non-Hodgkin lymphoma in HIV-infected patients

Nicolas Mounier, Michele Spina, Christian Gisselbrecht

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Patients infected with human immunodeficiency virus (HIV) are at greater risk of developing non-Hodgkin lymphoma than the general population and aggressive B-cell lymphoma has become one of the most common of the initial acquired immunodeficiency syndrome (AIDS)-defining illnesses. This review considers the prognostic factors and new approaches to the treatment of patients with AIDS-related lymphoma (ARL). As highly active antiretroviral therapy (HAART) became available, the survival of many ARL patients has become comparable to that of HIV-negative patients. This is partly due to the decrease in the incidence of opportunistic infections and improved prognosis. Both developments can also be attributed to new treatment strategies for ARL, such as the use of effective infusional regimens, Rituximab combinations and high-dose therapy with autologous stem-cell transplantation for relapsed disease. However, unresolved issues persist, such as the optimal therapy for patients with Burkitt ARL or central nervous system involvement.

Original languageEnglish
Pages (from-to)685-698
Number of pages14
JournalBritish Journal of Haematology
Volume136
Issue number5
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Non-Hodgkin's Lymphoma
AIDS-Related Lymphoma
HIV
Acquired Immunodeficiency Syndrome
Burkitt Lymphoma
Opportunistic Infections
Highly Active Antiretroviral Therapy
Stem Cell Transplantation
B-Cell Lymphoma
Therapeutics
Lymphoma
Central Nervous System
Survival
Incidence
Population

Keywords

  • AIDS-related lymphoma
  • Highly active antiretroviral therapy
  • Peripheral blood stem-cell transplantation
  • Prognosis
  • Rituximab

ASJC Scopus subject areas

  • Hematology

Cite this

Modern management of non-Hodgkin lymphoma in HIV-infected patients. / Mounier, Nicolas; Spina, Michele; Gisselbrecht, Christian.

In: British Journal of Haematology, Vol. 136, No. 5, 03.2007, p. 685-698.

Research output: Contribution to journalArticle

Mounier, Nicolas ; Spina, Michele ; Gisselbrecht, Christian. / Modern management of non-Hodgkin lymphoma in HIV-infected patients. In: British Journal of Haematology. 2007 ; Vol. 136, No. 5. pp. 685-698.
@article{9cd37e0f025e4a67bf83bdd6a8dda6ff,
title = "Modern management of non-Hodgkin lymphoma in HIV-infected patients",
abstract = "Patients infected with human immunodeficiency virus (HIV) are at greater risk of developing non-Hodgkin lymphoma than the general population and aggressive B-cell lymphoma has become one of the most common of the initial acquired immunodeficiency syndrome (AIDS)-defining illnesses. This review considers the prognostic factors and new approaches to the treatment of patients with AIDS-related lymphoma (ARL). As highly active antiretroviral therapy (HAART) became available, the survival of many ARL patients has become comparable to that of HIV-negative patients. This is partly due to the decrease in the incidence of opportunistic infections and improved prognosis. Both developments can also be attributed to new treatment strategies for ARL, such as the use of effective infusional regimens, Rituximab combinations and high-dose therapy with autologous stem-cell transplantation for relapsed disease. However, unresolved issues persist, such as the optimal therapy for patients with Burkitt ARL or central nervous system involvement.",
keywords = "AIDS-related lymphoma, Highly active antiretroviral therapy, Peripheral blood stem-cell transplantation, Prognosis, Rituximab",
author = "Nicolas Mounier and Michele Spina and Christian Gisselbrecht",
year = "2007",
month = "3",
doi = "10.1111/j.1365-2141.2006.06464.x",
language = "English",
volume = "136",
pages = "685--698",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "5",

}

TY - JOUR

T1 - Modern management of non-Hodgkin lymphoma in HIV-infected patients

AU - Mounier, Nicolas

AU - Spina, Michele

AU - Gisselbrecht, Christian

PY - 2007/3

Y1 - 2007/3

N2 - Patients infected with human immunodeficiency virus (HIV) are at greater risk of developing non-Hodgkin lymphoma than the general population and aggressive B-cell lymphoma has become one of the most common of the initial acquired immunodeficiency syndrome (AIDS)-defining illnesses. This review considers the prognostic factors and new approaches to the treatment of patients with AIDS-related lymphoma (ARL). As highly active antiretroviral therapy (HAART) became available, the survival of many ARL patients has become comparable to that of HIV-negative patients. This is partly due to the decrease in the incidence of opportunistic infections and improved prognosis. Both developments can also be attributed to new treatment strategies for ARL, such as the use of effective infusional regimens, Rituximab combinations and high-dose therapy with autologous stem-cell transplantation for relapsed disease. However, unresolved issues persist, such as the optimal therapy for patients with Burkitt ARL or central nervous system involvement.

AB - Patients infected with human immunodeficiency virus (HIV) are at greater risk of developing non-Hodgkin lymphoma than the general population and aggressive B-cell lymphoma has become one of the most common of the initial acquired immunodeficiency syndrome (AIDS)-defining illnesses. This review considers the prognostic factors and new approaches to the treatment of patients with AIDS-related lymphoma (ARL). As highly active antiretroviral therapy (HAART) became available, the survival of many ARL patients has become comparable to that of HIV-negative patients. This is partly due to the decrease in the incidence of opportunistic infections and improved prognosis. Both developments can also be attributed to new treatment strategies for ARL, such as the use of effective infusional regimens, Rituximab combinations and high-dose therapy with autologous stem-cell transplantation for relapsed disease. However, unresolved issues persist, such as the optimal therapy for patients with Burkitt ARL or central nervous system involvement.

KW - AIDS-related lymphoma

KW - Highly active antiretroviral therapy

KW - Peripheral blood stem-cell transplantation

KW - Prognosis

KW - Rituximab

UR - http://www.scopus.com/inward/record.url?scp=33846954413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846954413&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2006.06464.x

DO - 10.1111/j.1365-2141.2006.06464.x

M3 - Article

VL - 136

SP - 685

EP - 698

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 5

ER -