Modification of 35% carbon dioxide hypersensitivity across one week of treatment with clomipramine and fluvoxamine: A double-blind, randomized, placebo-controlled study

Giampaolo Perna, Angelo Bertani, Angela Gabriele, Ernestina Politi, Laura Bellodi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of short treatments (7 days) with clomipramine and fluvoxamine on the reactivity to inhalations of 35% CO2/65% O2 were compared in 39 panic patients who had positive responses to 35% CO2 inhalations. A double-blind, randomized, placebo-controlled design was applied. Each patient was given the 35% CO2 challenge on days 0 (before starting treatment), 3, and 7. Patients on placebo did not report any significant changes in their reactivity to 35% CO2 across the three sessions, whereas patients on clomipramine and fluvoxamine reported a significant attenuation of the reactivity on day 7. These results indicate that treatments with clomipramine and fluvoxamine decrease hypersensitivity to 35% CO2 after a few days, suggesting a relevant role of the modulation of CO2 sensitivity by the serotonergic system in antipanic properties of these compounds.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalJournal of Clinical Psychopharmacology
Volume17
Issue number3
DOIs
Publication statusPublished - Jun 1997

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Modification of 35% carbon dioxide hypersensitivity across one week of treatment with clomipramine and fluvoxamine: A double-blind, randomized, placebo-controlled study'. Together they form a unique fingerprint.

Cite this