Abstract
Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEVl/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.
| Original language | English |
|---|---|
| Journal | Neurological Sciences |
| Volume | 23 |
| Issue number | SUPPL. 2 |
| DOIs | |
| Publication status | Published - Sep 2002 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Modification of respiratory function parameters in patients with severe Parkinson's disease. / De Pandis, M. F.; Starace, A.; Stefanelli, F.; Marruzzo, P.; Meoli, I.; De Simone, G.; Prati, R.; Stocchi, F.
In: Neurological Sciences, Vol. 23, No. SUPPL. 2, 09.2002.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modification of respiratory function parameters in patients with severe Parkinson's disease
AU - De Pandis, M. F.
AU - Starace, A.
AU - Stefanelli, F.
AU - Marruzzo, P.
AU - Meoli, I.
AU - De Simone, G.
AU - Prati, R.
AU - Stocchi, F.
PY - 2002/9
Y1 - 2002/9
N2 - Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEVl/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.
AB - Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEVl/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036757599&partnerID=8YFLogxK
U2 - 10.1007/s100720200074
DO - 10.1007/s100720200074
M3 - Article
C2 - 12548348
AN - SCOPUS:0036757599
VL - 23
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - SUPPL. 2
ER -