Modification of respiratory function parameters in patients with severe Parkinson's disease

M. F. De Pandis, A. Starace, F. Stefanelli, P. Marruzzo, I. Meoli, G. De Simone, R. Prati, F. Stocchi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEVl/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.

Original languageEnglish
JournalNeurological Sciences
Volume23
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2002

Fingerprint

Parkinson Disease
Blood Gas Analysis
Respiratory Function Tests
Lung Diseases
Cause of Death
Cardiovascular Diseases
Lung
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

De Pandis, M. F., Starace, A., Stefanelli, F., Marruzzo, P., Meoli, I., De Simone, G., ... Stocchi, F. (2002). Modification of respiratory function parameters in patients with severe Parkinson's disease. Neurological Sciences, 23(SUPPL. 2). https://doi.org/10.1007/s100720200074

Modification of respiratory function parameters in patients with severe Parkinson's disease. / De Pandis, M. F.; Starace, A.; Stefanelli, F.; Marruzzo, P.; Meoli, I.; De Simone, G.; Prati, R.; Stocchi, F.

In: Neurological Sciences, Vol. 23, No. SUPPL. 2, 09.2002.

Research output: Contribution to journalArticle

De Pandis, MF, Starace, A, Stefanelli, F, Marruzzo, P, Meoli, I, De Simone, G, Prati, R & Stocchi, F 2002, 'Modification of respiratory function parameters in patients with severe Parkinson's disease', Neurological Sciences, vol. 23, no. SUPPL. 2. https://doi.org/10.1007/s100720200074
De Pandis MF, Starace A, Stefanelli F, Marruzzo P, Meoli I, De Simone G et al. Modification of respiratory function parameters in patients with severe Parkinson's disease. Neurological Sciences. 2002 Sep;23(SUPPL. 2). https://doi.org/10.1007/s100720200074
De Pandis, M. F. ; Starace, A. ; Stefanelli, F. ; Marruzzo, P. ; Meoli, I. ; De Simone, G. ; Prati, R. ; Stocchi, F. / Modification of respiratory function parameters in patients with severe Parkinson's disease. In: Neurological Sciences. 2002 ; Vol. 23, No. SUPPL. 2.
@article{f6dfbd677399492e92b6d0ee2d2d4b01,
title = "Modification of respiratory function parameters in patients with severe Parkinson's disease",
abstract = "Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during {"}on{"} and {"}off{"} states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEVl/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.",
author = "{De Pandis}, {M. F.} and A. Starace and F. Stefanelli and P. Marruzzo and I. Meoli and {De Simone}, G. and R. Prati and F. Stocchi",
year = "2002",
month = "9",
doi = "10.1007/s100720200074",
language = "English",
volume = "23",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Modification of respiratory function parameters in patients with severe Parkinson's disease

AU - De Pandis, M. F.

AU - Starace, A.

AU - Stefanelli, F.

AU - Marruzzo, P.

AU - Meoli, I.

AU - De Simone, G.

AU - Prati, R.

AU - Stocchi, F.

PY - 2002/9

Y1 - 2002/9

N2 - Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEVl/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.

AB - Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEVl/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.

UR - http://www.scopus.com/inward/record.url?scp=0036757599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036757599&partnerID=8YFLogxK

U2 - 10.1007/s100720200074

DO - 10.1007/s100720200074

M3 - Article

C2 - 12548348

AN - SCOPUS:0036757599

VL - 23

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - SUPPL. 2

ER -