Modification of ultrasonographically measured endometrial thickness after discontinuation of adjuvant therapy with tamoxifen in postmenopausal breast cancer patients

M. Valenzano Menada, A. Papadia, P. Lorenzi, S. Costantini, G. F. Bertelli, N. Ragni

Research output: Contribution to journalArticle

Abstract

Introduction: The aim of this study was to evaluate endometrial changes after five years of tamoxifen treatment by measuring endometrial thickness with transvaginal ultrasonography. Materials and Methods: Fifty-five asymptomatic postmenopausal women who had assumed tamoxifen, 20 mg daily, for five years were controlled six months after discontinuation of the therapy. Of these 42 were followed-up at 12 months. Statistical analysis was performed using the analysis of variance for repeated measures and the Anova test; p <0.05 was considered statistically significant. Results: We found a significant reduction in endometrial thickness at six months (p = 0.0046) and at 12 months (p = 0.0003) but not between six and 12 months (p = 0.06). Conclusion: A statistically significant reduction in endometrial thickness after discontinuation of tamoxifen therapy was found. This can probably be attributed to the cessation of the estrogenic side-effects of tamoxifen therapy.

Original languageEnglish
Pages (from-to)321-323
Number of pages3
JournalEuropean Journal of Gynaecological Oncology
Volume25
Issue number3
Publication statusPublished - 2004

Keywords

  • Endometrial thickness
  • Tamoxifen
  • Ultrasonography

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Fingerprint Dive into the research topics of 'Modification of ultrasonographically measured endometrial thickness after discontinuation of adjuvant therapy with tamoxifen in postmenopausal breast cancer patients'. Together they form a unique fingerprint.

  • Cite this