Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects

Giuseppe Derosa, Angela D'Angelo, Sibilla A T Salvadeo, Ilaria Ferrari, Elena Fogari, Alessia Gravina, Roberto Mereu, Ilaria Palumbo, Pamela Maffioli, Sabrina Randazzo, Arrigo F G Cicero

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the effect of an oral glucose tolerance test (OGTT) on the level of biomarkers of vascular remodelling. We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D). All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin (ADP), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) before and after OGTT. Nitrites/nitrates decrease was present after 60, 90, 120, and 180 min in both groups. Nitrite/nitrate levels were decreased at baseline, after 30 and 60 min in D group compared to H group. ADP decrease was present after 90, 120, and 180 min, in both groups. ADP levels were lower in D group than in H group during OGTT. MMP-2 increase was present after 60, 90, and 120 min in H group, while MMP-2 increase was observed after 90, 120, and 180 min in D group. MMP-2 levels were higher in D group than in H group during OGTT. MMP-9 increase was present in H group after 60, 90, 120, and 180 min, while MMP-9 increase was observed after 90, 120, and 180 min in D group. MMP-9 levels were higher in D group than in H group during OGTT. Postprandial glycemia induces an acute increase in biomarkers of vascular remodelling.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalMicrovascular Research
Volume79
Issue number2
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Endothelial stress
  • Metalloproteinases
  • OGTT
  • Type 2 diabetes mellitus
  • Vascular remodelling

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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