Modifications in the papillary thyroid cancer gene profile over the last 15 years

Cristina Romei, Laura Fugazzola, Efisio Puxeddu, Francesco Frasca, David Viola, Marina Muzza, Sonia Moretti, Maria Luisa Nicolosi, Carlotta Giani, Valentina Cirello, Nicola Avenia, Stefania Rossi, Paolo Vitti, Aldo Pinchera, Rossella Elisei

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40 Citations (Scopus)

Abstract

Background: Evidence for an increased prevalence of BRAFV600E mutations has been documented in recent decades. The aim of this study was to evaluate the prevalence of both RET/PTC rearrangements and BRAFV600E mutations in an Italian cohort of papillary thyroid carcinoma (PTC) patients followed at the Endocrine Units of Pisa, Milano, and Perugia from 1996-2010. Patients and Methods: In total, 401 PTC patients were examined and grouped according to the time of surgery: group 1, 1996-2000; group 2, 2001-2005; and group 3, 2006-2010. Patients were analyzed for clinical, pathological, and molecular features. In parallel, the molecular characteristics of 459 PTC from Sicily were studied. Results: The genetic profiles of the three groups were significantly different (PV600E mutations increased over the same period, from 28% in group 1 (28of100) to 48.9% in group 2 (73 of 148) and 58.1% in group 3 (89 of 153). A consistent increase in BRAFV600E prevalence was observed in the Sicilian group (PV600E mutations. In addition, the mean age at diagnosis increased and tumor size decreased over the study period.

Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number9
DOIs
Publication statusPublished - Sep 2012

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Neoplasm Genes
Surgery
Tumors
Genes
Mutation
Sicily
Papillary Thyroid cancer
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Modifications in the papillary thyroid cancer gene profile over the last 15 years. / Romei, Cristina; Fugazzola, Laura; Puxeddu, Efisio; Frasca, Francesco; Viola, David; Muzza, Marina; Moretti, Sonia; Nicolosi, Maria Luisa; Giani, Carlotta; Cirello, Valentina; Avenia, Nicola; Rossi, Stefania; Vitti, Paolo; Pinchera, Aldo; Elisei, Rossella.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 9, 09.2012.

Research output: Contribution to journalArticle

Romei, C, Fugazzola, L, Puxeddu, E, Frasca, F, Viola, D, Muzza, M, Moretti, S, Nicolosi, ML, Giani, C, Cirello, V, Avenia, N, Rossi, S, Vitti, P, Pinchera, A & Elisei, R 2012, 'Modifications in the papillary thyroid cancer gene profile over the last 15 years', Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 9. https://doi.org/10.1210/jc.2012-1269
Romei, Cristina ; Fugazzola, Laura ; Puxeddu, Efisio ; Frasca, Francesco ; Viola, David ; Muzza, Marina ; Moretti, Sonia ; Nicolosi, Maria Luisa ; Giani, Carlotta ; Cirello, Valentina ; Avenia, Nicola ; Rossi, Stefania ; Vitti, Paolo ; Pinchera, Aldo ; Elisei, Rossella. / Modifications in the papillary thyroid cancer gene profile over the last 15 years. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 9.
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AU - Fugazzola, Laura

AU - Puxeddu, Efisio

AU - Frasca, Francesco

AU - Viola, David

AU - Muzza, Marina

AU - Moretti, Sonia

AU - Nicolosi, Maria Luisa

AU - Giani, Carlotta

AU - Cirello, Valentina

AU - Avenia, Nicola

AU - Rossi, Stefania

AU - Vitti, Paolo

AU - Pinchera, Aldo

AU - Elisei, Rossella

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