Modifications of Apomorphine test response in Parkinson's disease patients during bilaterally GPi stimulation

A. Peppe, M. Pierantozzi, P. Stanzione, G. Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

Internal globus pallidum (Gpi) deep stimulation can be improve severely disabled parkinsonian patients. We studied 3 Idiopatic Parkinson's disease patients (PD) (mean age at the symptoms onset: 37.3 years; mean of symptoms duration: 16 years, mean of L-dopa treatment: 11.5 years, LTTS duration: 7.5years. All patients were operated bilaterally in Gpi, the electrodes were implanted according to preoperative MRI and intraoperative microrecordings and clinical evaluation. The PD patients were evaluatebefore surgery in OFF drug and after surgery in drug OFF and stimulator OFF and in sdru OFF and : abnormal involuntary movement scale (0-4,tot 16) were utilized in 3 conditions to evaluate the modifications of symptoms after different subcoutaneously injections of Apomorphine. The results showed a drastic reduction of involuntar movement after surgery during apomorfine test with stimulator ON. while the response to apomorfine it is similar to before surgery if the stimulator is OFF. These result underKes the important role of Gpi on the genesis od LTTS in PD patients.

Original languageEnglish
Pages (from-to)135
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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