Modificazioni dei marcatori di rimodellamento osseo in pazienti trattati con neridronato per osteoporosi indotta da glucocorticoidi

Translated title of the contribution: Modifications of markers of bone resorption in patients affected by glucocorticoid induced osteoporosis (GIOP) treated with neridronate

Maurizio Benucci, Stefano Dolenti, Gianantonio Saviola, Mariangela Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

Almost 30-50% of patients on long-term therapy with glucocorticoids (GC), especially those affected by rheumatic diseases, develop glucocorticoid induced osteoporosis (GIOP) and osteoporosis-related fractures. To assess the effects of neridronate versus placebo on markers of bone resorption in rheumatic patients affected by GIOP (as defined by a T Score reduction >2.5; mean BMD L2-L4), sixty-two female patients [age: 68.89±9.45 (mean±SD)] affected by different rheumatic diseases, like rheumatoid arthritis, polymyalgia rheumatica, Sjögren syndrome in treatment with a mean prednisone-equivalent daily dose of 6.44±2.4 mg/day, were enrolled in an open trial. The patients were divided in 2 groups: group A (26 patients) assuming daily calcium 1 g and vitamin D 800 UI and group B (36 patients) assuming daily calcium (1000mg) and vitamin D (800 UI) and neridronate (25 mg im /30 days). The patients were evaluated for serum and urinary bone markers, basely (TO) and after 6 months of therapy (T6). After 6 months of therapy (T6), bone markers were significantly reduced in group B in respect to group A: OHPr - 41.64% (p

Translated title of the contributionModifications of markers of bone resorption in patients affected by glucocorticoid induced osteoporosis (GIOP) treated with neridronate
Original languageItalian
Pages (from-to)24-27
Number of pages4
JournalRecenti Progressi in Medicina
Volume97
Issue number1
Publication statusPublished - Jan 2006

ASJC Scopus subject areas

  • Medicine(all)

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