Modified expression of peripheral blood lymphocyte muscarinic cholinergic receptors in asthmatic children

Emanuela Cherubini, Luca Tabbì, Davide Scozzi, Salvatore Mariotta, Elena Galli, Rossella Carello, Simona Avitabile, Seyed Koshrow Tayebati, Francesco Amenta, Claudia De Vitis, Rita Mancini, Alberto Ricci

Research output: Contribution to journalArticlepeer-review

Abstract

Lymphocytes possess an independent cholinergic system. We assessed the expression of muscarinic cholinergic receptors in lymphocytes from 49 asthmatic children and 10 age matched controls using Western blot. We demonstrated that CD4. + and CD8. + T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls. M2 and M4 receptor increase was strictly related with IgE and fraction of exhaled nitric oxide (FeNO) measurements and with impairment in objective measurements of airway obstruction. Increased lymphocyte muscarinic cholinergic receptor expression may concur with lung cholinergic dysfunction and with inflammatory molecular framework in asthma.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalJournal of Neuroimmunology
Volume284
DOIs
Publication statusPublished - Jul 15 2015

Keywords

  • Asthma
  • Human
  • Muscarinic receptors
  • Western blot

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

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