Modified glasgow prognostic score is associated with risk of recurrence in bladder cancer patients after radical Cystectomy: A multicenter experience

Matteo Ferro, Ottavio De Cobelli, Carlo Buonerba, Giuseppe Di Lorenzo, Marco Capece, Dario Bruzzese, Riccardo Autorino, Danilo Bottero, Antonio Cioffi, Deliu Victor Matei, Michele Caraglia, Marco Borghesi, Ettore De Berardinis, Gian Maria Busetto, Riccardo Giovannone, Giuseppe Lucarelli, Pasquale Ditonno, Sisto Perdona, Pierluigi Bove, Luigi CastaldoRodolfo Hurle, Gennaro Musi, Antonio Brescia, Michele Olivieri, Amelia Cimmino, Vincenzo Altieri, Rocco Damiano, Francesco Cantiello, Vincenzo Serretta, Sabino De Placido, Vincenzo Mirone, Guru Sonpavde, Daniela Terracciano

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, many studies explored the role of inflammation parameters in the prognosis of urinary cancers, but the results were not consistent. The modified Glasgow Prognostic Score (mGPS), a systemic inflammation marker, is a prognostic marker in various types of cancers. The aim of the present study was to investigate the usefulness of the preoperative mGPS as predictor of recurrence-free (RFS), overall (OS), and cancer-specific (CSS) survivals in a large cohort of urothelial bladder cancer (UBC) patients. A total of 1037 patients with UBC were included in this study with a median follow-up of 22 months (range 360 months). An mGPS0 was observed in 646 patients (62.3%), mGPS1 in 297 patients (28.6 %), and mGPS2 in 94 patients (9.1%). In our study cohort, subjects with an mGPS equal to 2 had a significantly shorter median RFS compared with subjects with mGPS equal to 1 (16 vs 19 months, hazard ratio [HR] 1.54, 95% CI 1.311.81, P

Original languageEnglish
Pages (from-to)e1861
JournalMedicine (United States)
Volume94
Issue number42
DOIs
Publication statusPublished - Oct 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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