Modifying bone scaffold architecture in vivo with permanent magnets to facilitate fixation of magnetic scaffolds

S. Panseri, A. Russo, M. Sartori, G. Giavaresi, M. Sandri, M. Fini, M. C. Maltarello, T. Shelyakova, A. Ortolani, A. Visani, V. Dediu, A. Tampieri, M. Marcacci

Research output: Contribution to journalArticlepeer-review

Abstract

The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were used to magnetize the biomaterials with direct nucleation on collagen fibres or impregnation techniques. Minimally invasive surgery was performed on 12 rabbits to implant cylindrical NdFeB magnets in close proximity to magnetic scaffolds within the lateral condyles of the distal femoral epiphyses.Under this static magnetic field we demonstrated, for the first time in vivo, that the ability to modify the scaffold architecture could influence tissue regeneration obtaining a well-ordered tissue. Moreover, the association between NdFeB magnet and magnetic scaffolds represents a potential technique to ensure scaffold fixation avoiding micromotion at the tissue/biomaterial interface.

Original languageEnglish
Pages (from-to)432-439
Number of pages8
JournalBone
Volume56
Issue number2
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Bone
  • Fixation
  • Magnetic field
  • Oriented architecture
  • Scaffold

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

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