Modulation of acute and chronic inflammation of the lung by GITR and its ligand

Giuseppe Nocentini, Salvatore Cuzzocrea, Rodolfo Bianchini, Emanuela Mazzon, Carlo Riccardi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Abstract

Glucocorticoid-induced TNFR-related (GITR) protein, a member of the tumor necrosis factor receptor superfamily, is expressed in many components of the innate and adaptive immune system and modulates their activation following interaction with its ligand (GITRL). Here we review and discuss results described in previous publications where the role of the GITR/GITRL system in lung inflammation was evaluated using two experimental systems. We also discuss the proinflammatory role played by the GITR/GITRL system and the potential use of GITR fusion protein in inhibiting inflammation.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages380-391
Number of pages12
Volume1107
DOIs
Publication statusPublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1107
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Glucocorticoid-Induced TNFR-Related Protein
Glucocorticoids
Pneumonia
Modulation
Ligands
Tumor Necrosis Factor Receptors
Immune System
Immune system
Inflammation
Fusion reactions
Chemical activation
Proteins

Keywords

  • Co-activating molecule
  • Fusion protein
  • Innate immunity
  • Leukocyte extravasation
  • Lung inflammation
  • Tumor necrosis factor superfamily

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nocentini, G., Cuzzocrea, S., Bianchini, R., Mazzon, E., & Riccardi, C. (2007). Modulation of acute and chronic inflammation of the lung by GITR and its ligand. In Annals of the New York Academy of Sciences (Vol. 1107, pp. 380-391). (Annals of the New York Academy of Sciences; Vol. 1107). https://doi.org/10.1196/annals.1381.040

Modulation of acute and chronic inflammation of the lung by GITR and its ligand. / Nocentini, Giuseppe; Cuzzocrea, Salvatore; Bianchini, Rodolfo; Mazzon, Emanuela; Riccardi, Carlo.

Annals of the New York Academy of Sciences. Vol. 1107 2007. p. 380-391 (Annals of the New York Academy of Sciences; Vol. 1107).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nocentini, G, Cuzzocrea, S, Bianchini, R, Mazzon, E & Riccardi, C 2007, Modulation of acute and chronic inflammation of the lung by GITR and its ligand. in Annals of the New York Academy of Sciences. vol. 1107, Annals of the New York Academy of Sciences, vol. 1107, pp. 380-391. https://doi.org/10.1196/annals.1381.040
Nocentini G, Cuzzocrea S, Bianchini R, Mazzon E, Riccardi C. Modulation of acute and chronic inflammation of the lung by GITR and its ligand. In Annals of the New York Academy of Sciences. Vol. 1107. 2007. p. 380-391. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1381.040
Nocentini, Giuseppe ; Cuzzocrea, Salvatore ; Bianchini, Rodolfo ; Mazzon, Emanuela ; Riccardi, Carlo. / Modulation of acute and chronic inflammation of the lung by GITR and its ligand. Annals of the New York Academy of Sciences. Vol. 1107 2007. pp. 380-391 (Annals of the New York Academy of Sciences).
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