Modulation of affective symptoms and resting state activity by brain stimulation in a treatment-resistant case of obsessive-compulsive disorder

C. Volpato, F. Piccione, M. Cavinato, D. Duzzi, S. Schiff, L. Foscolo, A. Venneri

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) on psychopathological symptoms and resting state brain activity was assessed in a patient with obsessive-compulsive disorder (OCD). tDCS and rTMS had no effect on OC symptoms. tDCS, however, improved depression and anxiety. Functional magnetic resonance imaging at baseline showed an interhemispheric asymmetry with hyperactivation of the left and hypoactivation of the right anterior neural circuits. A reduction of interhemispheric imbalance was detected after tDCS but not after rTMS. tDCS seems to be more effective than rTMS in restoring interhemispheric imbalance and improving anxiety and depression in OCD.

Original languageEnglish
Pages (from-to)360-370
Number of pages11
JournalNeurocase
Volume19
Issue number4
DOIs
Publication statusPublished - Aug 2013

Keywords

  • fMRI
  • OCD
  • Resting state
  • rTMS
  • tDCS

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

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