Modulation of all-trans retinoid acid pharmacokinetics in acute promyelocytic leukaemia by prolonged interferon-α therapy

M. Lazzarino, A. Corso, M. B. Regazzi, I. Iacona, C. Bernasconi

Research output: Contribution to journalArticle

Abstract

Continuous treatment with all-trans retinoid acid (ATRA) induces accelerated drug catabolism which is considered responsible for acquired resistance to ATRA. We studied the effect of interferon-α2a (IFN) on ATRA pharmacokinetics in two patients with acute promyelocytic leukaemia (APL) in complete remission maintained bv alternating 15 d of IFN and 15 d of ATRA. Day 15 ATRA levels obtained during IFN + ATRA treatment were significantly higher than those observed in patients maintained on ATRA alone. In one patient IFN was discontinued and day 15 ATRA levels decreased to those observed in patients scheduled for maintenance with ATRA alone. In our two patients IFN substantially reduced the induction of ATRA catabolism, indicating a potential role for IFN in modulating ATRA pharmacokinetics.

Original languageEnglish
Pages (from-to)928-930
Number of pages3
JournalBritish Journal of Haematology
Volume90
Issue number4
Publication statusPublished - 1995

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Keywords

  • acute promyelocytic leukaemia
  • all-trans retinoid acid
  • interferon

ASJC Scopus subject areas

  • Hematology

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