Modulation of apoptosis in human lymphocytes by adenosine analogues

Daniela Barbieri, Claudio Franceschi, Emidio Camaioni, Stefano Costanzi, Sauro Vittori, Rosaria Volpini, Gloria Cristalli

Research output: Contribution to journalArticlepeer-review

Abstract

We previously described that 2-chloroadenosine (2CA) and 2-chloro-2'- deoxyadenosine (2CdA) induced apoptosis in human peripheral blood mononuclear cells (PBMC). In this study we tested different adenosine analogues on PBMC and we found that the modifications introduced in the 2CA structure prevented the molecule from exerting its apoptotic effect. On the other hand, substitutions on 2CdA are tolerated, although with a significant decrease in activity.

Original languageEnglish
Pages (from-to)2533-2538
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number18
DOIs
Publication statusPublished - Sep 22 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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