Modulation of biofilm of strains isolated from patients with chronic obstructive pulmonary disease by levofloxacin, moxifloxacin, ciprofloxacin, amoxicillin/clavulanic acid and ceftriaxone

L. Drago, R. Mattina, D. Legnani, C. L. Romanò, E. Vianello, C. Ricci, E. De Vecchi

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of levofloxacin, moxifloxacin, ciprofloxacin, amoxicillin/clavulanic acid and ceftriaxone to interfere on biofilm produced by Pseudomonas aeruginosa, Haemophilus influenzae and Streptococcus pneumoniae isolated from patients with chronic obstructive pulmonary disease was evaluated. The effects of antibiotics were evaluated on formation of biofilm (at 1/2, 1/4 and 1/8 X MIC) and on preformed biofilm (at epithelial lining fluid peak concentrations) by means of a spectrophotometric method. Levofloxacin was the most active compound followed by ciprofloxacin, moxifloxacin and amoxicillin/ clavulanic acid and ceftriaxone. Levofloxacin may contribute to clear the reservoir of pathogens involved in chronic obstructive pulmonary disease, thus leading to decreased occurrence of acute exacerbations.

Original languageEnglish
Pages (from-to)1027-1035
Number of pages9
JournalInternational Journal of Immunopathology and Pharmacology
Volume24
Issue number4
Publication statusPublished - Oct 2011

Keywords

  • β-lactams
  • Cephalosporins
  • Fluoroquinolones
  • Haemophilus influenzae
  • Pseudomonas aeruginosa
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

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