Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.
|Number of pages||7|
|Publication status||Published - 1997|
ASJC Scopus subject areas