Modulation of cell proliferation by the integrin cytoplasmic domain

D. Q. Zheng; M. Fornaro; C. J M Bofetiado; G. Tallini; S. Bosari; L. R. Languino

Modulation of cell proliferation by the integrin cytoplasmic domain

D. Q. Zheng, M. Fornaro, C. J M Bofetiado, G. Tallini, S. Bosari, L. R. Languino

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.

Original language	English
Pages (from-to)	1434-1440
Number of pages	7
Journal	Kidney International
Volume	51
Issue number	5
Publication status	Published - 1997

ASJC Scopus subject areas

Nephrology

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title = "Modulation of cell proliferation by the integrin cytoplasmic domain",

abstract = "Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.",

author = "Zheng, {D. Q.} and M. Fornaro and Bofetiado, {C. J M} and G. Tallini and S. Bosari and Languino, {L. R.}",

year = "1997",

language = "English",

volume = "51",

pages = "1434--1440",

journal = "Kidney International",

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T1 - Modulation of cell proliferation by the integrin cytoplasmic domain

AU - Zheng, D. Q.

AU - Fornaro, M.

AU - Bofetiado, C. J M

AU - Tallini, G.

AU - Bosari, S.

AU - Languino, L. R.

PY - 1997

Y1 - 1997

N2 - Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.

AB - Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.

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