Abstract
Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.
| Original language | English |
|---|---|
| Pages (from-to) | 1434-1440 |
| Number of pages | 7 |
| Journal | Kidney International |
| Volume | 51 |
| Issue number | 5 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Nephrology
Cite this
Modulation of cell proliferation by the integrin cytoplasmic domain. / Zheng, D. Q.; Fornaro, M.; Bofetiado, C. J M; Tallini, G.; Bosari, S.; Languino, L. R.
In: Kidney International, Vol. 51, No. 5, 1997, p. 1434-1440.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of cell proliferation by the integrin cytoplasmic domain
AU - Zheng, D. Q.
AU - Fornaro, M.
AU - Bofetiado, C. J M
AU - Tallini, G.
AU - Bosari, S.
AU - Languino, L. R.
PY - 1997
Y1 - 1997
N2 - Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.
AB - Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030907852&partnerID=8YFLogxK
M3 - Article
C2 - 9150455
AN - SCOPUS:0030907852
VL - 51
SP - 1434
EP - 1440
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 5
ER -