Modulation of cell proliferation by the integrin cytoplasmic domain

D. Q. Zheng, M. Fornaro, C. J M Bofetiado, G. Tallini, S. Bosari, L. R. Languino

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.

Original languageEnglish
Pages (from-to)1434-1440
Number of pages7
JournalKidney International
Volume51
Issue number5
Publication statusPublished - 1997

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Integrins
Cell Proliferation
Cell Survival
Epithelial Cells
Phenotype
Growth
In Vitro Techniques
adhesion receptor

ASJC Scopus subject areas

  • Nephrology

Cite this

Zheng, D. Q., Fornaro, M., Bofetiado, C. J. M., Tallini, G., Bosari, S., & Languino, L. R. (1997). Modulation of cell proliferation by the integrin cytoplasmic domain. Kidney International, 51(5), 1434-1440.

Modulation of cell proliferation by the integrin cytoplasmic domain. / Zheng, D. Q.; Fornaro, M.; Bofetiado, C. J M; Tallini, G.; Bosari, S.; Languino, L. R.

In: Kidney International, Vol. 51, No. 5, 1997, p. 1434-1440.

Research output: Contribution to journalArticle

Zheng, DQ, Fornaro, M, Bofetiado, CJM, Tallini, G, Bosari, S & Languino, LR 1997, 'Modulation of cell proliferation by the integrin cytoplasmic domain', Kidney International, vol. 51, no. 5, pp. 1434-1440.
Zheng DQ, Fornaro M, Bofetiado CJM, Tallini G, Bosari S, Languino LR. Modulation of cell proliferation by the integrin cytoplasmic domain. Kidney International. 1997;51(5):1434-1440.
Zheng, D. Q. ; Fornaro, M. ; Bofetiado, C. J M ; Tallini, G. ; Bosari, S. ; Languino, L. R. / Modulation of cell proliferation by the integrin cytoplasmic domain. In: Kidney International. 1997 ; Vol. 51, No. 5. pp. 1434-1440.
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