Modulation of cell proliferation by the integrin cytoplasmic domain

D. Q. Zheng, M. Fornaro, C. J M Bofetiado, G. Tallini, S. Bosari, L. R. Languino

Research output: Contribution to journalArticlepeer-review

Abstract

Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The β(1C) integrin, an alternatively spliced form of β(1A), containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of β(1C) correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.

Original languageEnglish
Pages (from-to)1434-1440
Number of pages7
JournalKidney International
Volume51
Issue number5
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Nephrology

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