Abstract
The neuropeptide CGRP is transiently expressed at neonatal stages in the rat olivocerebellar system, while high affinity binding sites for the peptide are permanently expressed in the molecular layer of the adult cerebellum. In this study, an increase in the density of cerebellar high affinity binding sites for calcitonin gene-related peptide (CGRP) is induced by harmaline, given at a dose appropriate to induce tremor. The present results, taken together with the demonstration that harmaline is a potent stimulator of the olivocerebellar system, suggest that the expression of cerebellar CGRP receptors can be modulated by the level of activity in the cerebellar afferents.
| Original language | English |
|---|---|
| Pages (from-to) | 215-217 |
| Number of pages | 3 |
| Journal | NeuroReport |
| Volume | 1 |
| Issue number | 3 |
| Publication status | Published - 1990 |
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Keywords
- Cerebellar cortex
- CGRP binding sites
- Harmaline
- Olivocerebellar system
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Modulation of cerebellar CGRP binding sites induced by climbing fibre activation. / Rosina, Anna; Morara, Stefano; Provini, Luciano; Forloni, Gianluigi.
In: NeuroReport, Vol. 1, No. 3, 1990, p. 215-217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of cerebellar CGRP binding sites induced by climbing fibre activation
AU - Rosina, Anna
AU - Morara, Stefano
AU - Provini, Luciano
AU - Forloni, Gianluigi
PY - 1990
Y1 - 1990
N2 - The neuropeptide CGRP is transiently expressed at neonatal stages in the rat olivocerebellar system, while high affinity binding sites for the peptide are permanently expressed in the molecular layer of the adult cerebellum. In this study, an increase in the density of cerebellar high affinity binding sites for calcitonin gene-related peptide (CGRP) is induced by harmaline, given at a dose appropriate to induce tremor. The present results, taken together with the demonstration that harmaline is a potent stimulator of the olivocerebellar system, suggest that the expression of cerebellar CGRP receptors can be modulated by the level of activity in the cerebellar afferents.
AB - The neuropeptide CGRP is transiently expressed at neonatal stages in the rat olivocerebellar system, while high affinity binding sites for the peptide are permanently expressed in the molecular layer of the adult cerebellum. In this study, an increase in the density of cerebellar high affinity binding sites for calcitonin gene-related peptide (CGRP) is induced by harmaline, given at a dose appropriate to induce tremor. The present results, taken together with the demonstration that harmaline is a potent stimulator of the olivocerebellar system, suggest that the expression of cerebellar CGRP receptors can be modulated by the level of activity in the cerebellar afferents.
KW - Cerebellar cortex
KW - CGRP binding sites
KW - Harmaline
KW - Olivocerebellar system
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UR - http://www.scopus.com/inward/citedby.url?scp=0025542382&partnerID=8YFLogxK
M3 - Article
C2 - 1966605
AN - SCOPUS:0025542382
VL - 1
SP - 215
EP - 217
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 3
ER -