Modulation of cyclin D1 expression in human tumoral parathyroid cells: Effects of growth factors and calcium sensing receptor activation

S. Corbetta, C. Eller-Vainicher, L. Vicentini, A. Lania, G. Mantovani, P. Beck-Peccoz, A. Spada

Research output: Contribution to journalArticlepeer-review

Abstract

The study investigated cyclin D1 regulation by growth factors and calcium sensing receptor (CaSR) in human tumoral parathyroid cells. Basic fibroblast and epidermal growth factors increased cyclin D1 and phosphorylated extracellular signal-regulated kinases (pERK1/2) levels that were both efficiently inhibited by CaSR agonists. By contrast, in growth factors-free medium cyclin D1 levels were either unaffected or stimulated by CaSR activation independently from ERK1/2 pathway. Transforming growth factor β (TGFβ) reduced cyclin D1 levels in the majority of tumors, this effect being not influenced by CaSR activation and menin expression levels. In conclusion, in parathyroid tumors cyclin D1 expression was modulated by growth factors and CaSR activation. These data further support the oncogenic role of cyclin D1, which resulted to be target for stimulation by bFGF and EGF and inhibition by CaSR and TGFβ signalling in the parathyroid.

Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalCancer Letters
Volume255
Issue number1
DOIs
Publication statusPublished - Sep 18 2007

Keywords

  • Calcium sensing receptor
  • Cyclin D1
  • Menin
  • Parathyroids

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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