Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate "altered" cells?

Michele Sommariva, Loris De Cecco, Elda Tagliabue, Andrea Balsari

Research output: Contribution to journalArticle

Abstract

We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response.

Original languageEnglish
Pages (from-to)258-259
Number of pages2
JournalOncoImmunology
Volume1
Issue number2
DOIs
Publication statusPublished - 2012

Keywords

  • Altered cells
  • Chemotherapy
  • DNA repair
  • Immune cell
  • Ovarian cancer
  • Toll-like receptor 9

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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