Modulation of endothelial hemostatic properties: An active role in the host response

H. Gerlach, C. Esposito, D. M. Stern

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

As the cells forming the luminal vascular surface, endothelium regulates both barrier function, and pro- and anticoagulant reactions. Endothelial cells can do this by controlling the expression of cell surface molecules, such as receptors that regulate the hemostatic balance and those that affect permeability across the endothelial monolayer. This regulation occurs in response to enviromental stimuli, such as cytokines, which have a central role in inflammation, or glucose-modified proteins, which accumulate in the vasculature in aging and diabetes and are associated with vascular complications. The endothelial cell emerges as a dynamic regulator maintaining homeostasis in the quiescent state and contributing to the pathogenesis of vascular lesions in the stimulated state.

Original languageEnglish
Pages (from-to)15-24
Number of pages10
JournalAnnual Review of Medicine
Volume41
Publication statusPublished - 1990

Fingerprint

Endothelial cells
Hemostatics
Blood Vessels
Endothelial Cells
Modulation
Vascular Endothelium
Medical problems
Anticoagulants
Monolayers
Permeability
Homeostasis
Aging of materials
Cells
Cytokines
Inflammation
Glucose
Molecules
Proteins

Keywords

  • coagulation
  • cytokine
  • thrombosis
  • vascular permeability

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Modulation of endothelial hemostatic properties : An active role in the host response. / Gerlach, H.; Esposito, C.; Stern, D. M.

In: Annual Review of Medicine, Vol. 41, 1990, p. 15-24.

Research output: Contribution to journalReview article

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