Abstract
As the cells forming the luminal vascular surface, endothelium regulates both barrier function, and pro- and anticoagulant reactions. Endothelial cells can do this by controlling the expression of cell surface molecules, such as receptors that regulate the hemostatic balance and those that affect permeability across the endothelial monolayer. This regulation occurs in response to enviromental stimuli, such as cytokines, which have a central role in inflammation, or glucose-modified proteins, which accumulate in the vasculature in aging and diabetes and are associated with vascular complications. The endothelial cell emerges as a dynamic regulator maintaining homeostasis in the quiescent state and contributing to the pathogenesis of vascular lesions in the stimulated state.
| Original language | English |
|---|---|
| Pages (from-to) | 15-24 |
| Number of pages | 10 |
| Journal | Annual Review of Medicine |
| Volume | 41 |
| Publication status | Published - 1990 |
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Keywords
- coagulation
- cytokine
- thrombosis
- vascular permeability
ASJC Scopus subject areas
- Cell Biology
- Medicine(all)
Cite this
Modulation of endothelial hemostatic properties : An active role in the host response. / Gerlach, H.; Esposito, C.; Stern, D. M.
In: Annual Review of Medicine, Vol. 41, 1990, p. 15-24.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Modulation of endothelial hemostatic properties
T2 - An active role in the host response
AU - Gerlach, H.
AU - Esposito, C.
AU - Stern, D. M.
PY - 1990
Y1 - 1990
N2 - As the cells forming the luminal vascular surface, endothelium regulates both barrier function, and pro- and anticoagulant reactions. Endothelial cells can do this by controlling the expression of cell surface molecules, such as receptors that regulate the hemostatic balance and those that affect permeability across the endothelial monolayer. This regulation occurs in response to enviromental stimuli, such as cytokines, which have a central role in inflammation, or glucose-modified proteins, which accumulate in the vasculature in aging and diabetes and are associated with vascular complications. The endothelial cell emerges as a dynamic regulator maintaining homeostasis in the quiescent state and contributing to the pathogenesis of vascular lesions in the stimulated state.
AB - As the cells forming the luminal vascular surface, endothelium regulates both barrier function, and pro- and anticoagulant reactions. Endothelial cells can do this by controlling the expression of cell surface molecules, such as receptors that regulate the hemostatic balance and those that affect permeability across the endothelial monolayer. This regulation occurs in response to enviromental stimuli, such as cytokines, which have a central role in inflammation, or glucose-modified proteins, which accumulate in the vasculature in aging and diabetes and are associated with vascular complications. The endothelial cell emerges as a dynamic regulator maintaining homeostasis in the quiescent state and contributing to the pathogenesis of vascular lesions in the stimulated state.
KW - coagulation
KW - cytokine
KW - thrombosis
KW - vascular permeability
UR - http://www.scopus.com/inward/record.url?scp=0025317629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025317629&partnerID=8YFLogxK
M3 - Review article
C2 - 2184719
AN - SCOPUS:0025317629
VL - 41
SP - 15
EP - 24
JO - Annual Review of Medicine
JF - Annual Review of Medicine
SN - 0066-4219
ER -