Modulation of epidermal growth factor receptor tyrosine phosphorylation by tumor necrosis factor

L. Guazzoni, P. Perego, P. Banfi, F. Zunino

Research output: Contribution to journalArticle

Abstract

The effects of tumor necrosis factor (TNF) on epidermal growth factor (EGF) receptor tyrosine phosphorylation were investigated in Swiss 3T3 cells, which are sensitive to TNF action. At cytotoxic levels, TNF produced an appreciable inhibition of EGF-induced autophosphorylation of the receptor. A similar inhibition was detected even after prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) which produces down-regulation of protein kinase C (PKC). According to this finding. TNF does not induce phosphorylation of the 80 kDa PKC-specific substrate. These results support the hypothesis that the inhibition of EGF receptor tyrosine phosphorylation is not mediated via stimulation of PKC activity in intact Swiss 3T3 cells.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalCancer Letters
Volume57
Issue number2
DOIs
Publication statusPublished - May 1 1991

Keywords

  • epidermal growth factor
  • tumor necrosis factor

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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