Modulation of experimental allergic encephalomyelitis in Lewis rats by administration of a peptide of Fas ligand

Emilio Ciusani, Maurizio Gelati, Simona Frigerio, Bianca Pollo, Giorgio Massa, Paola Sacerdote, Alberto E. Panerai, Andrea Salmaggi

Research output: Contribution to journalArticle

Abstract

The effects of modulation of apoptosis in experimental allergic encephalomyelitis (EAE) in Lewis rats have been investigated using a peptide of the Fas-Ligand protein (FasL-p). The peptide was administered both subcutaneously and intra-cerebro-ventricularly (i.c.v.) after EAE induction. Rats treated subcutaneously with FasL-p showed a worse clinical score as compared to saline treated animals, while i.c.v, treatment with FasL-p did not modify significantly the severity of EAE. Apoptotic lymphomonocytes (identified by TUNEL) infiltrating the brain and the spinal cord were decreased in rats treated i.c.v, with FasL-p. The data suggest that the Fas/Fas-ligand pathway may be modulated by treatments with peptides of Fas-Ligand and that it may be at work within the central nervous system in EAE.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalJournal of Autoimmunity
Volume17
Issue number4
DOIs
Publication statusPublished - Dec 1 2001

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Keywords

  • Apoptosis
  • EAE
  • Fas
  • Neuroimmunology

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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