Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells

Barbara Matteoli, Francesco Broccolo, Massimo Oggioni, Antonio Scaccino, Francesco Formica, Giulia Ciccarese, Francesco Drago, Lisa Fusetti, Susanna Esposito, Luca Ceccherini-Nelli

Research output: Contribution to journalArticle

Abstract

Aim: To evaluate the gene expression changes that occur soon after the active infection of two susceptible cell types with human herpesvirus 8 (HHV-8). Materials & methods: The expression profile of 282 human genes involved in the inflammatory process was investigated in HHV-8 A1 or C3 subtype-infected and mock-infected human epithelial cells and lymphoid cells. Results: The HHV-8-induced transcriptional profiles in the epithelial and lymphoid cells were very different. A robust increase in the expression was found in genes belonging to different categories, especially the categories of inflammation response and signal transduction. Conclusion: These results indicate that during early infection, HHV-8 induces a variety of cell type-specific processes, thus providing infection signatures useful as potential targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)619-629
Number of pages11
JournalFuture Virology
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

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Human Herpesvirus 8
Epithelial Cells
Lymphocytes
Gene Expression
Infection
Genes
Signal Transduction
Inflammation
Therapeutics

Keywords

  • gene expression
  • HHV-8
  • Kaposi's sarcoma

ASJC Scopus subject areas

  • Virology

Cite this

Matteoli, B., Broccolo, F., Oggioni, M., Scaccino, A., Formica, F., Ciccarese, G., ... Ceccherini-Nelli, L. (2016). Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells. Future Virology, 11(9), 619-629. https://doi.org/10.2217/fvl-2016-0063

Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells. / Matteoli, Barbara; Broccolo, Francesco; Oggioni, Massimo; Scaccino, Antonio; Formica, Francesco; Ciccarese, Giulia; Drago, Francesco; Fusetti, Lisa; Esposito, Susanna; Ceccherini-Nelli, Luca.

In: Future Virology, Vol. 11, No. 9, 01.09.2016, p. 619-629.

Research output: Contribution to journalArticle

Matteoli, B, Broccolo, F, Oggioni, M, Scaccino, A, Formica, F, Ciccarese, G, Drago, F, Fusetti, L, Esposito, S & Ceccherini-Nelli, L 2016, 'Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells', Future Virology, vol. 11, no. 9, pp. 619-629. https://doi.org/10.2217/fvl-2016-0063
Matteoli, Barbara ; Broccolo, Francesco ; Oggioni, Massimo ; Scaccino, Antonio ; Formica, Francesco ; Ciccarese, Giulia ; Drago, Francesco ; Fusetti, Lisa ; Esposito, Susanna ; Ceccherini-Nelli, Luca. / Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells. In: Future Virology. 2016 ; Vol. 11, No. 9. pp. 619-629.
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