Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells

Barbara Matteoli, Francesco Broccolo, Massimo Oggioni, Antonio Scaccino, Francesco Formica, Giulia Ciccarese, Francesco Drago, Lisa Fusetti, Susanna Esposito, Luca Ceccherini-Nelli

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate the gene expression changes that occur soon after the active infection of two susceptible cell types with human herpesvirus 8 (HHV-8). Materials & methods: The expression profile of 282 human genes involved in the inflammatory process was investigated in HHV-8 A1 or C3 subtype-infected and mock-infected human epithelial cells and lymphoid cells. Results: The HHV-8-induced transcriptional profiles in the epithelial and lymphoid cells were very different. A robust increase in the expression was found in genes belonging to different categories, especially the categories of inflammation response and signal transduction. Conclusion: These results indicate that during early infection, HHV-8 induces a variety of cell type-specific processes, thus providing infection signatures useful as potential targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)619-629
Number of pages11
JournalFuture Virology
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • gene expression
  • HHV-8
  • Kaposi's sarcoma

ASJC Scopus subject areas

  • Virology

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