Modulation of genes involved in zinc homeostasis in old low-grade atherosclerotic patients under effects of HMG-CoA reductase inhibitors

Laura Costarelli, Elisa Muti, Marco Malavolta, Robertina Giacconi, Catia Cipriano, Davide Sartini, Monica Emanuelli, Mauro Silvestrini, Leandro Provinciali, Beatrice Gobbi, Eugenio Mocchegiani

Research output: Contribution to journalArticlepeer-review

Abstract

Taking into account the antioxidant properties of zinc, it is difficult to explain the beneficial effects of HMG-CoA reductase inhibitors in the context of a well-known decreased zinc status. Therefore, intracellular zinc homeostasis was studied in patients with low-grade carotid atherosclerosis under treatment with HMG-CoA reductase inhibitors using a custom microarray-based approach developed by pooling information across microarray studies. Experimental data unravel an active zinc signaling in PBMC from low-grade atherosclerotic patients under lipid reduction therapy, suggesting that monitoring intracellular zinc status could be a key factor for an optimal strategy and targeting a level of intervention.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalRejuvenation Research
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

ASJC Scopus subject areas

  • Ageing

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