TY - JOUR
T1 - Modulation of genes involved in zinc homeostasis in old low-grade atherosclerotic patients under effects of HMG-CoA reductase inhibitors
AU - Costarelli, Laura
AU - Muti, Elisa
AU - Malavolta, Marco
AU - Giacconi, Robertina
AU - Cipriano, Catia
AU - Sartini, Davide
AU - Emanuelli, Monica
AU - Silvestrini, Mauro
AU - Provinciali, Leandro
AU - Gobbi, Beatrice
AU - Mocchegiani, Eugenio
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Taking into account the antioxidant properties of zinc, it is difficult to explain the beneficial effects of HMG-CoA reductase inhibitors in the context of a well-known decreased zinc status. Therefore, intracellular zinc homeostasis was studied in patients with low-grade carotid atherosclerosis under treatment with HMG-CoA reductase inhibitors using a custom microarray-based approach developed by pooling information across microarray studies. Experimental data unravel an active zinc signaling in PBMC from low-grade atherosclerotic patients under lipid reduction therapy, suggesting that monitoring intracellular zinc status could be a key factor for an optimal strategy and targeting a level of intervention.
AB - Taking into account the antioxidant properties of zinc, it is difficult to explain the beneficial effects of HMG-CoA reductase inhibitors in the context of a well-known decreased zinc status. Therefore, intracellular zinc homeostasis was studied in patients with low-grade carotid atherosclerosis under treatment with HMG-CoA reductase inhibitors using a custom microarray-based approach developed by pooling information across microarray studies. Experimental data unravel an active zinc signaling in PBMC from low-grade atherosclerotic patients under lipid reduction therapy, suggesting that monitoring intracellular zinc status could be a key factor for an optimal strategy and targeting a level of intervention.
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U2 - 10.1089/rej.2008.0665
DO - 10.1089/rej.2008.0665
M3 - Article
C2 - 18341426
AN - SCOPUS:42649116762
VL - 11
SP - 287
EP - 291
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -