Modulation of hippocampal LHRH receptors by sex steroids in the rat

Mohammed Badr, Bianca Marchetti, Georges Pelletier

Research output: Contribution to journalArticlepeer-review

Abstract

The modulation of brain LHRH receptors by sex steroids was assessed in the female rat hippocampus using in vitro autoradiography and iodinated [D-Ser (TBU)6, des-Gly-NH2 10]LHRH ethylamide as the radioligand. As evaluated by optical densitometry, the density of hippocampal LHRH receptors was increased by castration. In castrated animals, estradiol administration produced a small decrease in receptor concentration, whereas the concomitant administration of progesterone and estradiol as well as the injection of dihydrotestosterone induced a marked decrease in receptor density. Progesterone administration did not produce any significant change in receptor concentration. These results indicate that brain LHRH receptors can be modulated by sex steroids. Interestingly, this modulation of hippocampal LHRH receptors is similar to that previously observed in pituitary gland.

Original languageEnglish
Pages (from-to)441-442
Number of pages2
JournalPeptides
Volume9
Issue number2
DOIs
Publication statusPublished - 1988

Keywords

  • Autoradiography
  • Castration
  • Hippocampus
  • LHRH receptor
  • Sex steroids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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