Abstract
The effects of short treatments (7 days) with paroxetine and with reboxetine on the reactivity to inhalations of 35% carbon dioxide (CO 2)/65% oxygen (O2) were compared in 28 patients with Panic Disorder who had positive responses to 35% CO2 inhalations. A double-blind, randomized design was applied. Each patient was given the 35% CO2 challenge on days 0 (before starting the treatment) and 7. Anxiety reactivity to CO2 decreased significantly with both drugs but the decrease was significantly stronger in the group treated with paroxetine. The rate of patients whose reactivity has reduced of at least 50% after 7 days was significantly higher in the group treated with paroxetine (10/14, 71.5%) than in the one treated with reboxetine (3/14, 21.5%). These results indicate that the modulation of the serotonergic system is more relevant for CO2 hyperreactivity than the modulation of the noradrenergic one.
| Original language | English |
|---|---|
| Pages (from-to) | 277-282 |
| Number of pages | 6 |
| Journal | Journal of Clinical Psychopharmacology |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2004 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Modulation of hyperreactivity to 35% CO2 after one week of treatment with paroxetine and reboxetine : A double-blind, randomized study. / Perna, Giampaolo; Bertani, Angelo; Caldirola, Daniela; Di Pasquale, Danila; Migliarese, Giovanni; Bellodi, Laura.
In: Journal of Clinical Psychopharmacology, Vol. 24, No. 3, 06.2004, p. 277-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of hyperreactivity to 35% CO2 after one week of treatment with paroxetine and reboxetine
T2 - A double-blind, randomized study
AU - Perna, Giampaolo
AU - Bertani, Angelo
AU - Caldirola, Daniela
AU - Di Pasquale, Danila
AU - Migliarese, Giovanni
AU - Bellodi, Laura
PY - 2004/6
Y1 - 2004/6
N2 - The effects of short treatments (7 days) with paroxetine and with reboxetine on the reactivity to inhalations of 35% carbon dioxide (CO 2)/65% oxygen (O2) were compared in 28 patients with Panic Disorder who had positive responses to 35% CO2 inhalations. A double-blind, randomized design was applied. Each patient was given the 35% CO2 challenge on days 0 (before starting the treatment) and 7. Anxiety reactivity to CO2 decreased significantly with both drugs but the decrease was significantly stronger in the group treated with paroxetine. The rate of patients whose reactivity has reduced of at least 50% after 7 days was significantly higher in the group treated with paroxetine (10/14, 71.5%) than in the one treated with reboxetine (3/14, 21.5%). These results indicate that the modulation of the serotonergic system is more relevant for CO2 hyperreactivity than the modulation of the noradrenergic one.
AB - The effects of short treatments (7 days) with paroxetine and with reboxetine on the reactivity to inhalations of 35% carbon dioxide (CO 2)/65% oxygen (O2) were compared in 28 patients with Panic Disorder who had positive responses to 35% CO2 inhalations. A double-blind, randomized design was applied. Each patient was given the 35% CO2 challenge on days 0 (before starting the treatment) and 7. Anxiety reactivity to CO2 decreased significantly with both drugs but the decrease was significantly stronger in the group treated with paroxetine. The rate of patients whose reactivity has reduced of at least 50% after 7 days was significantly higher in the group treated with paroxetine (10/14, 71.5%) than in the one treated with reboxetine (3/14, 21.5%). These results indicate that the modulation of the serotonergic system is more relevant for CO2 hyperreactivity than the modulation of the noradrenergic one.
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U2 - 10.1097/01.jcp.0000125682.97466.3c
DO - 10.1097/01.jcp.0000125682.97466.3c
M3 - Article
C2 - 15118481
AN - SCOPUS:2442710377
VL - 24
SP - 277
EP - 282
JO - Journal of Clinical Psychopharmacology
JF - Journal of Clinical Psychopharmacology
SN - 0271-0749
IS - 3
ER -